Stoichiometry of ubiquitin-binding proteins directs DSB repair

por Bakkenist, Christopher J, Vaziri, Cyrus
Publicado 2013

Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells

por Gandhi, Manoj, Evdokimova, Viktoria N., Cuenco, Karen T., Bakkenist, Christopher J., Nikiforov, Yuri E.
Publicado 2013

WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells

por Moiseeva, Tatiana N., Qian, Chenao, Sugitani, Norie, Osmanbeyoglu, Hatice U., Bakkenist, Christopher J.
Publicado 2019

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromos...

por Evdokimova, Viktoria N., Gandhi, Manoj, Nikitski, Alyaksandr V., Bakkenist, Christopher J., Nikiforov, Yuri E.
Publicado 2018

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma

por Beumer, Jan H., Fu, Katherine Y., Anyang, Bean N., Siegfried, Jill M., Bakkenist, Christopher J.
Publicado 2015

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

por Gamper, Armin M., Rofougaran, Reza, Watkins, Simon C., Greenberger, Joel S., Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2013

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

por Moiseeva, Tatiana, Hood, Brian, Schamus, Sandy, O’Connor, Mark J., Conrads, Thomas P., Bakkenist, Christopher J.
Publicado 2017

Radiation therapy induces the DNA damage response in peripheral blood

por Bakkenist, Christopher J., Czambel, R. Kenneth, Clump, David A., Greenberger, Joel S., Beumer, Jan H., Schmitz, John C.
Publicado 2013

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells

por Bakkenist, Christopher J., Czambel, R. Kenneth, Hershberger, Pamela A., Tawbi, Hussein, Beumer, Jan H., Schmitz, John C.
Publicado 2015

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

por Vendetti, Frank P., Lau, Alan, Schamus, Sandra, Conrads, Thomas P., O'Connor, Mark J., Bakkenist, Christopher J.
Publicado 2015

Dose-Dependent Bioavailability and Tissue Distribution of the ATR Inhibitor AZD6738 (ceralasertib) in Mice

por Kiesel, Brian F., Guo, Jianxia, Parise, Robert. A, Venkataramanan, Raman, Clump, David A., Bakkenist, Christopher J., Beumer, Jan H.
Publicado 2022

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

por Yamamoto, Kenta, Wang, Yunyue, Jiang, Wenxia, Liu, Xiangyu, Dubois, Richard L., Lin, Chyuan-Sheng, Ludwig, Thomas, Bakkenist, Christopher J., Zha, Shan
Publicado 2012

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

por Menolfi, Demis, Jiang, Wenxia, Lee, Brian J., Moiseeva, Tatiana, Shao, Zhengping, Estes, Verna, Frattini, Mark G., Bakkenist, Christopher J., Zha, Shan
Publicado 2018

Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation

por Uttam, Shikhar, Bista, Rajan K., Staton, Kevin, Alexandrov, Sergey, Choi, Serah, Bakkenist, Christopher J., Hartman, Douglas J., Brand, Randall E., Liu, Yang
Publicado 2013

Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice

por Wells, Alexandra I., Grimes, Kalena A., Kim, Kenneth, Branche, Emilie, Bakkenist, Christopher J., DePas, William H., Shresta, Sujan, Coyne, Carolyn B.
Publicado 2021

The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination

por Martino, Julieta, Brunette, Gregory J, Barroso-González, Jonathan, Moiseeva, Tatiana N, Smith, Chelsea M, Bakkenist, Christopher J, O’Sullivan, Roderick J, Bernstein, Kara A
Publicado 2019

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

por Moiseeva, Tatiana N., Yin, Yandong, Calderon, Michael J., Qian, Chenao, Schamus-Haynes, Sandra, Sugitani, Norie, Osmanbeyoglu, Hatice U., Rothenberg, Eli, Watkins, Simon C., Bakkenist, Christopher J.
Publicado 2019

Syngeneic tobacco carcinogen–induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden

por Stabile, Laura P., Kumar, Vinod, Gaither-Davis, Autumn, Huang, Eric H., Vendetti, Frank P., Devadassan, Princey, Dacic, Sanja, Bao, Riyue, Steinman, Richard A., Burns, Timothy F., Bakkenist, Christopher J.
Publicado 2021

The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy

por Vendetti, Frank P., Pandya, Pinakin, Clump, David A., Schamus-Haynes, Sandra, Tavakoli, Meysam, diMayorca, Maria, Islam, Naveed M., Chang, Jina, Delgoffe, Greg M., Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2023

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice

por Sun, Rui, Guo, Siying, Shuda, Yoko, Chakka, Anish B., Rigatti, Lora H., Zhao, Guangyi, Ali, Mohammed A. E., Park, Christopher Y., Chandran, Uma, Yu, Jian, Bakkenist, Christopher J., Shuda, Masahiro, Moore, Patrick S., Chang, Yuan
Publicado 2023