A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein

por Schnapp, Gisela, Hoevels, Yvette, Bakker, Remko A., Schreiner, Patrick, Klein, Thomas, Nar, Herbert
Publicado 2020

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy

por Boyer, David S., Rippmann, Joerg F., Ehrlich, Michael S., Bakker, Remko A., Chong, Victor, Nguyen, Quan Dong
Publicado 2021

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

por Nakamura, Shinsuke, Nishinaka, Anri, Hidaka, Yae, Shimazawa, Masamitsu, Thomas, Leo, Bakker, Remko A., Hara, Hideaki
Publicado 2022

Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases

por Weigelt, Carina M., Zippel, Nina, Fuchs, Holger, Rimpelä, Anna-Kaisa, Schönberger, Tanja, Stierstorfer, Birgit, Bakker, Remko A., Redemann, Norbert H.
Publicado 2022

AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice

por Weigelt, Carina M., Fuchs, Holger, Schönberger, Tanja, Stierstorfer, Birgit, Strobel, Benjamin, Lamla, Thorsten, Ciossek, Thomas, Bakker, Remko A., Redemann, Norbert H.
Publicado 2021

Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy

por Zippel, Nina, Kenny, Cynthia Hess, Wu, Helen, Garneau, Michel, Kroe-Barrett, Rachel, Gupta, Priyanka, Low, Sarah, Bakker, Remko A., Thomas, Leo
Publicado 2022

Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells

por Markert, Elke K., Klein, Holger, Viollet, Coralie, Rust, Werner, Strobel, Benjamin, Kauschke, Stefan G., Makovoz, Bar, Neubauer, Heike, Bakker, Remko A., Blenkinsop, Timothy A.
Publicado 2022

In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

por Becker, Kolja, Klein, Holger, Simon, Eric, Viollet, Coralie, Haslinger, Christian, Leparc, German, Schultheis, Christian, Chong, Victor, Kuehn, Markus H., Fernandez-Albert, Francesc, Bakker, Remko A.
Publicado 2021

Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

por Lebon, Cecile, Neubauer, Heike, Berdugo, Marianne, Delaunay, Kimberley, Markert, Elke, Becker, Kolja, Baum-Kroker, Katja S., Prestle, Jürgen, Fuchs, Holger, Bakker, Remko A., Behar-Cohen, Francine
Publicado 2021

Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

por Becker, Kolja, Weigelt, Carina M., Fuchs, Holger, Viollet, Coralie, Rust, Werner, Wyatt, Hannah, Huber, Jochen, Lamla, Thorsten, Fernandez-Albert, Francesc, Simon, Eric, Zippel, Nina, Bakker, Remko A., Klein, Holger, Redemann, Norbert H.
Publicado 2022