Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β‐Cell Pathology

por Balboa, Diego, Saarimäki‐Vire, Jonna, Otonkoski, Timo
Publicado 2018

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes

por Balboa, Diego, Iworima, Diepiriye G., Kieffer, Timothy J.
Publicado 2021

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

por Balboa, Diego, Prasad, Rashmi B., Groop, Leif, Otonkoski, Timo
Publicado 2019

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

por Balboa, Diego, Weltner, Jere, Eurola, Solja, Trokovic, Ras, Wartiovaara, Kirmo, Otonkoski, Timo
Publicado 2015

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1

por Tamminen, Kaisa, Balboa, Diego, Toivonen, Sanna, Pakarinen, Mikko P., Wiener, Zoltan, Alitalo, Kari, Otonkoski, Timo
Publicado 2015

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

por Närvä, Elisa, Stubb, Aki, Guzmán, Camilo, Blomqvist, Matias, Balboa, Diego, Lerche, Martina, Saari, Markku, Otonkoski, Timo, Ivaska, Johanna
Publicado 2017

A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions

por Nikkanen, Joni, Landoni, Juan Cruz, Balboa, Diego, Haugas, Maarja, Partanen, Juha, Paetau, Anders, Isohanni, Pirjo, Brilhante, Virginia, Suomalainen, Anu
Publicado 2017

Human pluripotent reprogramming with CRISPR activators

por Weltner, Jere, Balboa, Diego, Katayama, Shintaro, Bespalov, Maxim, Krjutškov, Kaarel, Jouhilahti, Eeva-Mari, Trokovic, Ras, Kere, Juha, Otonkoski, Timo
Publicado 2018

Differentiating functional human islet-like aggregates from pluripotent stem cells

por Barsby, Tom, Ibrahim, Hazem, Lithovius, Väinö, Montaser, Hossam, Balboa, Diego, Vähäkangas, Eliisa, Chandra, Vikash, Saarimäki-Vire, Jonna, Otonkoski, Timo
Publicado 2022

Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

por Elbasani, Endrit, Falasco, Francesca, Gramolelli, Silvia, Nurminen, Veijo, Günther, Thomas, Weltner, Jere, Balboa, Diego, Grundhoff, Adam, Otonkoski, Timo, Ojala, Päivi M.
Publicado 2020

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells

por Lund, Carina, Yellapragada, Venkatram, Vuoristo, Sanna, Balboa, Diego, Trova, Sara, Allet, Cecile, Eskici, Nazli, Pulli, Kristiina, Giacobini, Paolo, Tuuri, Timo, Raivio, Taneli
Publicado 2020

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

por Konovalova, Svetlana, Liu, Xiaonan, Manjunath, Pooja, Baral, Sundar, Neupane, Nirajan, Hilander, Taru, Yang, Yang, Balboa, Diego, Terzioglu, Mügen, Euro, Liliya, Varjosalo, Markku, Tyynismaa, Henna
Publicado 2018

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

por Miguel-Escalada, Irene, Maestro, Miguel Ángel, Balboa, Diego, Elek, Anamaria, Bernal, Aina, Bernardo, Edgar, Grau, Vanessa, García-Hurtado, Javier, Sebé-Pedrós, Arnau, Ferrer, Jorge
Publicado 2022

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

por Balboa, Diego, Saarimäki-Vire, Jonna, Borshagovski, Daniel, Survila, Mantas, Lindholm, Päivi, Galli, Emilia, Eurola, Solja, Ustinov, Jarkko, Grym, Heli, Huopio, Hanna, Partanen, Juha, Wartiovaara, Kirmo, Otonkoski, Timo
Publicado 2018

Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells

por Asikainen, Suvi, Heikkinen, Liisa, Juhila, Juuso, Holm, Frida, Weltner, Jere, Trokovic, Ras, Mikkola, Milla, Toivonen, Sanna, Balboa, Diego, Lampela, Riina, Icay, Katherine, Tuuri, Timo, Otonkoski, Timo, Wong, Garry, Hovatta, Outi
Publicado 2015

CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells

por Sokka, Joonas, Yoshihara, Masahito, Kvist, Jouni, Laiho, Laura, Warren, Andrew, Stadelmann, Christian, Jouhilahti, Eeva-Mari, Kilpinen, Helena, Balboa, Diego, Katayama, Shintaro, Kyttälä, Aija, Kere, Juha, Otonkoski, Timo, Weltner, Jere, Trokovic, Ras
Publicado 2022

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

por Beucher, Anthony, Miguel-Escalada, Irene, Balboa, Diego, De Vas, Matías G., Maestro, Miguel Angel, Garcia-Hurtado, Javier, Bernal, Aina, Gonzalez-Franco, Roser, Vargiu, Pierfrancesco, Heyn, Holger, Ravassard, Philippe, Ortega, Sagrario, Ferrer, Jorge
Publicado 2022

p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming

por Martin-Lopez, Marta, Maeso-Alonso, Laura, Fuertes-Alvarez, Sandra, Balboa, Diego, Rodríguez-Cortez, Virginia, Weltner, Jere, Diez-Prieto, Inmaculada, Davis, Andrew, Wu, Yaning, Otonkoski, Timo, Flores, Elsa R, Menéndez, Pablo, Marques, Margarita M, Marin, Maria C
Publicado 2017

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

por Montaser, Hossam, Patel, Kashyap A., Balboa, Diego, Ibrahim, Hazem, Lithovius, Väinö, Näätänen, Anna, Chandra, Vikash, Demir, Korcan, Acar, Sezer, Ben-Omran, Tawfeg, Colclough, Kevin, Locke, Jonathan M., Wakeling, Matthew, Lindahl, Maria, Hattersley, Andrew T., Saarimäki-Vire, Jonna, Otonkoski, Timo
Publicado 2021

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

por Chandra, Vikash, Ibrahim, Hazem, Halliez, Clémentine, Prasad, Rashmi B., Vecchio, Federica, Dwivedi, Om Prakash, Kvist, Jouni, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Barsby, Tom, Lithovius, Väinö, Artner, Isabella, Gopalakrishnan, Swetha, Groop, Leif, Mallone, Roberto, Eizirik, Decio L., Otonkoski, Timo
Publicado 2022