A mouse GITRl fusion protein drives T cell activation and antitumor activity in preclinical mouse models of cancer

por Leyland, Rebecca, Watkins, Amanda, Bamber, Lisa, Tigue, Natalie, Young, Lesley, Morrow, Michelle, Hammond, Scott, Wilkinson, Robert, Stewart, Ross
Publicado 2015

MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue

por Ghadially, Hormas, Brown, Lee, Lloyd, Chris, Lewis, Leeanne, Lewis, Arthur, Dillon, Janette, Sainson, Richard, Jovanovic, Jelena, Tigue, Natalie J, Bannister, David, Bamber, Lisa, Valge-Archer, Viia, Wilkinson, Robert W
Publicado 2017

A simeprevir-inducible molecular switch for the control of cell and gene therapies

por Chin, Stacey E., Schindler, Christina, Vinall, Lisa, Dodd, Roger B., Bamber, Lisa, Legg, Sandrine, Sigurdardottir, Anna, Rees, D. Gareth, Malcolm, Tim I. M., Spratley, Samantha J., Granéli, Cecilia, Sumner, Jonathan, Tigue, Natalie J.
Publicado 2023

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

por Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross
Publicado 2017