The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors

por Matias, Pedro M., Baek, Sung Hee, Bandeiras, Tiago M., Dutta, Anindya, Houry, Walid A., Llorca, Oscar, Rosenbaum, Jean
Publicado 2015

Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity

por Alves, Márcia, Lamego, Joana, Bandeiras, Tiago, Castro, Rute, Tomás, Hélio, Coroadinha, Ana Sofia, Costa, Júlia, Simplício, Ana Luisa
Publicado 2015

A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?

por Vicente, João B., Colaço, Henrique G., Malagrinò, Francesca, Santo, Paulo E., Gutierres, André, Bandeiras, Tiago M., Leandro, Paula, Brito, José A., Giuffrè, Alessandro
Publicado 2017

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

por Grädler, Ulrich, Schwarz, Daniel, Wegener, Ansgar, Eichhorn, Thomas, Bandeiras, Tiago M., Freitas, Micael C., Lammens, Alfred, Ganichkin, Oleg, Augustin, Martin, Minguzzi, Stefano, Becker, Frank, Bomke, Jörg
Publicado 2023

X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action

por Silva, Sara T. N., Brito, José A., Arranz, Rocío, Sorzano, Carlos Óscar S., Ebel, Christine, Doutch, James, Tully, Mark D., Carazo, José-María, Carrascosa, José L., Matias, Pedro M., Bandeiras, Tiago M.
Publicado 2018

Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods

por Zuhra, Karim, Sousa, Pedro M. F., Paulini, Giulia, Lemos, Ana Rita, Kalme, Zenta, Bisenieks, Imants, Bisenieks, Egils, Vigante, Brigita, Duburs, Gunars, Bandeiras, Tiago M., Saso, Luciano, Giuffrè, Alessandro, Vicente, João B.
Publicado 2019

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

por Clarke, Thomas L., Sanchez-Bailon, Maria Pilar, Chiang, Kelly, Reynolds, John J., Herrero-Ruiz, Joaquin, Bandeiras, Tiago M., Matias, Pedro M., Maslen, Sarah L., Skehel, J. Mark, Stewart, Grant S., Davies, Clare C.
Publicado 2017

NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis

por Abel, Yoann, Paiva, Ana C F, Bizarro, Jonathan, Chagot, Marie-Eve, Santo, Paulo E, Robert, Marie-Cécile, Quinternet, Marc, Vandermoere, Franck, Sousa, Pedro M F, Fort, Philippe, Charpentier, Bruno, Manival, Xavier, Bandeiras, Tiago M, Bertrand, Edouard, Verheggen, Céline
Publicado 2020

Extract2Chip—Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance

por Paiva, Ana C. F., Lemos, Ana R., Busse, Philipp, Martins, Madalena T., Silva, Diana O., Freitas, Micael C., Santos, Sandra P., Freire, Filipe, Barrey, Evelyne J., Manival, Xavier, Koetzner, Lisa, Heinrich, Timo, Wegener, Ansgar, Grädler, Ulrich, Bandeiras, Tiago M., Schwarz, Daniel, Sousa, Pedro M. F.
Publicado 2023

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

por Seixas, João D., Sousa, Bárbara B., Marques, Marta C., Guerreiro, Ana, Traquete, Rui, Rodrigues, Tiago, Albuquerque, Inês S., Sousa, Marcos F. Q., Lemos, Ana R., Sousa, Pedro M. F., Bandeiras, Tiago M., Wu, Di, Doyle, Shelby K., Robinson, Carol V., Koehler, Angela N., Corzana, Francisco, Matias, Pedro M., Bernardes, Gonçalo J. L.
Publicado 2020

Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer

por Silva, Gabriela, Sales-Dias, Joana, Casal, Diogo, Alves, Sara, Domenici, Giacomo, Barreto, Clara, Matos, Carolina, Lemos, Ana R., Matias, Ana T., Kucheryava, Khrystyna, Ferreira, Andreia, Moita, Maria Raquel, Braga, Sofia, Brito, Catarina, Cabral, M. Guadalupe, Casalou, Cristina, Barral, Duarte C., Sousa, Pedro M. F., Videira, Paula A., Bandeiras, Tiago M., Barbas, Ana
Publicado 2021

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

por Maurizy, Chloé, Quinternet, Marc, Abel, Yoann, Verheggen, Céline, Santo, Paulo E., Bourguet, Maxime, C.F. Paiva, Ana, Bragantini, Benoît, Chagot, Marie-Eve, Robert, Marie-Cécile, Abeza, Claire, Fabre, Philippe, Fort, Philippe, Vandermoere, Franck, M.F. Sousa, Pedro, Rain, Jean-Christophe, Charpentier, Bruno, Cianférani, Sarah, Bandeiras, Tiago M., Pradet-Balade, Bérengère, Manival, Xavier, Bertrand, Edouard
Publicado 2018

Production of high‐quality SARS‐CoV‐2 antigens: Impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance

por Castro, Rute, Nobre, Lígia S., Eleutério, Rute P., Thomaz, Mónica, Pires, António, Monteiro, Sandra M., Mendes, Sónia, Gomes, Ricardo A., Clemente, João J., Sousa, Marcos F. Q., Pinto, Filipe, Silva, Ana C., Freitas, Micael C., Lemos, Ana R., Akpogheneta, Onome, Kosack, Lindsay, Bergman, Marie‐Louise, Duarte, Nadia, Matoso, Paula, Costa, Júlia, Bandeiras, Tiago M., Gomes‐Alves, Patricia, Gonçalves, Carlos P., Demengeot, Jocelyne, Alves, Paula M.
Publicado 2021