Clonal selection and therapy resistance in acute leukaemias: mathematical modelling explains different proliferation patterns at diagnosis and relapse

por Stiehl, Thomas, Baran, Natalia, Ho, Anthony D., Marciniak-Czochra, Anna
Publicado 2014

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation

por George, Binsah, Kantarjian, Hagop, Baran, Natalia, Krocker, Joseph Douglas, Rios, Adan
Publicado 2021

Utilizing Synergistic Potential of Mitochondria-Targeting Drugs for Leukemia Therapy

por Panina, Svetlana B., Pei, Jingqi, Baran, Natalia, Konopleva, Marina, Kirienko, Natalia V.
Publicado 2020

A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs

por Panina, Svetlana B., Baran, Natalia, Brasil da Costa, Fabio H., Konopleva, Marina, Kirienko, Natalia V.
Publicado 2019

The cross-talk between macrophages and tumor cells as a target for cancer treatment

por Aizaz, Muhammad, Khan, Aakif, Khan, Faisal, Khan, Maria, Musad Saleh, Ebraheem Abdu, Nisar, Maryum, Baran, Natalia
Publicado 2023

Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia

por Timofeeva, Natalia, Ayres, Mary L., Baran, Natalia, Santiago-O’Farrill, Janice M., Bildik, Gamze, Lu, Zhen, Konopleva, Marina, Gandhi, Varsha
Publicado 2023

P460: ERK1/2 INHIBITION OVERCOMES RESSITANCE TO BCL2 INHIBITION IN ACUTE MYELOID LEUKEMIA BY IMPACT ON MITOCHONDRIAL DYNAMICS AND FUNCTION

por Sharma, Priyanka, Piya, Sujan, Baran, Natalia, Zal, Anna, Zhang, Qi, Munck, Joanne, Dao, Kim-Hien, Sims, Martin, Andreeff, Michael, Borthakur, Gautam
Publicado 2023

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion...

por Drazkowska, Karolina, Tomecki, Rafal, Warminski, Marcin, Baran, Natalia, Cysewski, Dominik, Depaix, Anaïs, Kasprzyk, Renata, Kowalska, Joanna, Jemielity, Jacek, Sikorski, Pawel J
Publicado 2022

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation †

por Wojcik, Radoslaw, Baranowski, Marek R., Markiewicz, Lukasz, Kubacka, Dorota, Bednarczyk, Marcelina, Baran, Natalia, Wojtczak, Anna, Sikorski, Pawel J., Zuberek, Joanna, Kowalska, Joanna, Jemielity, Jacek
Publicado 2021

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

por Kleczewska, Natalia, Sikorski, Pawel J., Warminska, Zofia, Markiewicz, Lukasz, Kasprzyk, Renata, Baran, Natalia, Kwapiszewska, Karina, Karpinska, Aneta, Michalski, Jaroslaw, Holyst, Robert, Kowalska, Joanna, Jemielity, Jacek
Publicado 2021

The rarity of ALDH (+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients

por Hoang, Van T., Buss, Eike C., Wang, Wenwen, Hoffmann, Isabel, Raffel, Simon, Zepeda‐Moreno, Abraham, Baran, Natalia, Wuchter, Patrick, Eckstein, Volker, Trumpp, Andreas, Jauch, Anna, Ho, Anthony D., Lutz, Christoph
Publicado 2015

Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model

por Rytelewski, Mateusz, Harutyunyan, Karine, Baran, Natalia, Mallampati, Saradhi, Zal, M. Anna, Cavazos, Antonio, Butler, Jason M., Konoplev, Sergej, El Khatib, Mirna, Plunkett, Shane, Marszalek, Joseph R., Andreeff, Michael, Zal, Tomasz, Konopleva, Marina
Publicado 2020

PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity

por Koller, Paul, Baran, Natalia, Harutyunyan, Karine, Cavazos, Antonio, Mallampati, Saradhi, Chin, Renee L, Jiang, Zhou, Sun, Xian, Lee, Heng-Huan, Hsu, Jennifer L, Williams, Patrick, Huang, Xuelin, Curran, Michael A, Hung, Mien-Chie, Konopleva, Marina
Publicado 2023

Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL

por Piya, Sujan, Yang, Yaling, Bhattacharya, Seemana, Sharma, Priyanka, Ma, Huaxian, Mu, Hong, He, Hua, Ruvolo, Vivian, Baran, Natalia, Davis, R. Eric, Jain, Abhinav K., Konopleava, Marina, Kantarjian, Hagop, Andreeff, Michael, You, M. James, Borthakur, Gautam
Publicado 2022

S185: TARGETING DNA2 OVERCOMES METABOLIC REPROGRAMMING IN 1Q21 MULTIPLE MYELOMA

por Thongon, Natthakan, MA, Feiyang, Lockyer, Pamela, Baran, Natalia, Liu, Jintan, Class, Caleb, Tan, Lin, Storti, Paola, Marchica, Valentina, Ganan-Gomez, Irene, Wildeman, Bethany, Adema, Vera, Lorenzi, Philip, Fonseca, Rodrigo, Chesi, Marta, Manasanch, Elisabeth, Viale, Andrea, Colla, Simona
Publicado 2023

Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML

por Herbrich, Shelley, Baran, Natalia, Cai, Tianyu, Weng, Connie, Aitken, Marisa J L, Post, Sean M, Henderson, Jared, Shi, Chunhua, Havranek, Ondrej, Richard-Carpentier, Guillame, Sauvageau, Guy, Baggerly, Keith, Al-Atrash, Gheath, Davis, R Eric, Daver, Naval, Zha, Dongxing, Konopleva, Marina
Publicado 2021

SYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism

por Polak, Anna, Bialopiotrowicz, Emilia, Krzymieniewska, Beata, Wozniak, Jolanta, Stojak, Marta, Cybulska, Magdalena, Kaniuga, Ewelina, Mikula, Michał, Jablonska, Ewa, Gorniak, Patryk, Noyszewska-Kania, Monika, Szydlowski, Maciej, Piechna, Karolina, Piwocka, Katarzyna, Bugajski, Lukasz, Lech-Maranda, Ewa, Barankiewicz, Joanna, Kolkowska-Lesniak, Agnieszka, Patkowska, Elzbieta, Glodkowska-Mrowka, Eliza, Baran, Natalia, Juszczynski, Przemyslaw
Publicado 2020

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

por Saito, Kaori, Zhang, Qi, Yang, Haeun, Yamatani, Kotoko, Ai, Tomohiko, Ruvolo, Vivian, Baran, Natalia, Cai, Tianyu, Ma, Helen, Jacamo, Rodrigo, Kuruvilla, Vinitha, Imoto, Junichi, Kinjo, Sonoko, Ikeo, Kazuho, Moriya, Kaori, Suzuki, Koya, Miida, Takashi, Kim, Yong-Mi, Vellano, Christopher P., Andreeff, Michael, Marszalek, Joseph R., Tabe, Yoko, Konopleva, Marina
Publicado 2021

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

por Matre, Polina, Velez, Juliana, Jacamo, Rodrigo, Qi, Yuan, Su, Xiaoping, Cai, Tianyu, Chan, Steven M., Lodi, Alessia, Sweeney, Shannon R., Ma, Helen, Davis, Richard Eric, Baran, Natalia, Haferlach, Torsten, Su, Xiaohua, Flores, Elsa Renee, Gonzalez, Doriann, Konoplev, Sergej, Samudio, Ismael, DiNardo, Courtney, Majeti, Ravi, Schimmer, Aaron D., Li, Weiqun, Wang, Taotao, Tiziani, Stefano, Konopleva, Marina
Publicado 2016

A selective BCL-X(L) PROTAC degrader achieves safe and potent antitumor activity

por Khan, Sajid, Zhang, Xuan, Lv, Dongwen, Zhang, Qi, He, Yonghan, Zhang, Peiyi, Liu, Xingui, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Pei, Jing, Zhang, Weizhou, Sharma, Abhisheak, McCurdy, Christopher R., Kuruvilla, Vinitha M., Baran, Natalia, Ferrando, Adolfo A., Kim, Yong-mi, Rogojina, Anna, Houghton, Peter J., Huang, Guangcun, Hromas, Robert, Konopleva, Marina, Zheng, Guangrong, Zhou, Daohong
Publicado 2019