A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction

por Liang, Yanyu, Aguet, François, Barbeira, Alvaro N., Ardlie, Kristin, Im, Hae Kyung
Publicado 2021

Integrating predicted transcriptome from multiple tissues improves association detection

por Barbeira, Alvaro N., Pividori, Milton, Zheng, Jiamao, Wheeler, Heather E., Nicolae, Dan L., Im, Hae Kyung
Publicado 2019

Annotation-free quantification of RNA splicing using LeafCutter

por Li, Yang I, Knowles, David A, Humphrey, Jack, Barbeira, Alvaro N., Dickinson, Scott P., Im, Hae Kyung, Pritchard, Jonathan K
Publicado 2017

Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity

por Geeleher, Paul, Nath, Aritro, Wang, Fan, Zhang, Zhenyu, Barbeira, Alvaro N., Fessler, Jessica, Grossman, Robert L., Seoighe, Cathal, Stephanie Huang, R.
Publicado 2018

Imputed gene associations identify replicable trans‐acting genes enriched in transcription pathways and complex traits

por Wheeler, Heather E., Ploch, Sally, Barbeira, Alvaro N., Bonazzola, Rodrigo, Andaleon, Angela, Fotuhi Siahpirani, Alireza, Saha, Ashis, Battle, Alexis, Roy, Sushmita, Im, Hae Kyung
Publicado 2019

Fine‐mapping and QTL tissue‐sharing information improves the reliability of causal gene identification

por Barbeira, Alvaro N., Melia, Owen J., Liang, Yanyu, Bonazzola, Rodrigo, Wang, Gao, Wheeler, Heather E., Aguet, François, Ardlie, Kristin G., Wen, Xiaoquan, Im, Hae K.
Publicado 2020

sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

por He, Yuan, Chhetri, Surya B., Arvanitis, Marios, Srinivasan, Kaushik, Aguet, François, Ardlie, Kristin G., Barbeira, Alvaro N., Bonazzola, Rodrigo, Im, Hae Kyung, Brown, Christopher D., Battle, Alexis
Publicado 2020

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

por Barbeira, Alvaro N., Dickinson, Scott P., Bonazzola, Rodrigo, Zheng, Jiamao, Wheeler, Heather E., Torres, Jason M., Torstenson, Eric S., Shah, Kaanan P., Garcia, Tzintzuni, Edwards, Todd L., Stahl, Eli A., Huckins, Laura M., Nicolae, Dan L., Cox, Nancy J., Im, Hae Kyung
Publicado 2018

Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

por Gay, Nicole R., Gloudemans, Michael, Antonio, Margaret L., Abell, Nathan S., Balliu, Brunilda, Park, YoSon, Martin, Alicia R., Musharoff, Shaila, Rao, Abhiram S., Aguet, François, Barbeira, Alvaro N., Bonazzola, Rodrigo, Hormozdiari, Farhad, Ardlie, Kristin G., Brown, Christopher D., Im, Hae Kyung, Lappalainen, Tuuli, Wen, Xiaoquan, Montgomery, Stephen B.
Publicado 2020

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci

por Barbeira, Alvaro N., Bonazzola, Rodrigo, Gamazon, Eric R., Liang, Yanyu, Park, YoSon, Kim-Hellmuth, Sarah, Wang, Gao, Jiang, Zhuoxun, Zhou, Dan, Hormozdiari, Farhad, Liu, Boxiang, Rao, Abhiram, Hamel, Andrew R., Pividori, Milton D., Aguet, François, Bastarache, Lisa, Jordan, Daniel M., Verbanck, Marie, Do, Ron, Stephens, Matthew, Ardlie, Kristin, McCarthy, Mark, Montgomery, Stephen B., Segrè, Ayellet V., Brown, Christopher D., Lappalainen, Tuuli, Wen, Xiaoquan, Im, Hae Kyung
Publicado 2021

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer

por Kar, Siddhartha P., Considine, Daniel P.C., Tyrer, Jonathan P., Plummer, Jasmine T., Chen, Stephanie, Dezem, Felipe S., Barbeira, Alvaro N., Rajagopal, Padma S., Rosenow, Will T., Moreno, Fernando, Bodelon, Clara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, deFazio, Anna, Dörk, Thilo, Ekici, Arif B., Ewing, Ailith, Fountzilas, George, Goode, Ellen L., Hartman, Mikael, Heitz, Florian, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K., Huzarski, Tomasz, Jensen, Allan, Karlan, Beth Y., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kjaer, Susanne K., Klapdor, Rüdiger, Köbel, Martin, Li, Jingmei, Liebrich, Clemens, May, Taymaa, Olsson, Håkan, Permuth, Jennifer B., Peterlongo, Paolo, Radice, Paolo, Ramus, Susan J., Riggan, Marjorie J., Risch, Harvey A., Saloustros, Emmanouil, Simard, Jacques, Szafron, Lukasz M., Titus, Linda, Thompson, Cheryl L., Vierkant, Robert A., Winham, Stacey J., Zheng, Wei, Doherty, Jennifer A., Berchuck, Andrew, Lawrenson, Kate, Im, Hae Kyung, Manichaikul, Ani W., Pharoah, Paul D.P., Gayther, Simon A., Schildkraut, Joellen M.
Publicado 2021