Impact of Autosomal Recessive Juvenile Parkinson’s Disease Mutations on the Structure and Interactions of the Parkin Ubiquitin-like Domain

por Safadi, Susan S., Barber, Kathryn R., Shaw, Gary S.
Publicado 2011

The HIP2~Ubiquitin Conjugate Forms a Non-Compact Monomeric Thioester during Di-Ubiquitin Synthesis

por Cook, Benjamin W., Barber, Kathryn R., Shilton, Brian H., Shaw, Gary S.
Publicado 2015

Ataxin-3 Is a Multivalent Ligand for the Parkin Ubl Domain

por Bai, Jane J., Safadi, Susan S., Mercier, Pascal, Barber, Kathryn R., Shaw, Gary S.
Publicado 2013

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

por Dunkerley, Karen M., Rintala-Dempsey, Anne C., Salzano, Giulia, Tadayon, Roya, Hadi, Dania, Barber, Kathryn R., Walden, Helen, Shaw, Gary S.
Publicado 2022

Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity

por Kumar, Atul, Chaugule, Viduth K, Condos, Tara E C, Barber, Kathryn R, Johnson, Clare, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Knebel, Axel, Shaw, Gary S, Walden, Helen
Publicado 2017

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

por Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S
Publicado 2018

The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation

por Maitland, Matthew E. R., Onea, Gabriel, Chiasson, Christopher A., Wang, Xu, Ma, Jun, Moor, Sarah E., Barber, Kathryn R., Lajoie, Gilles A., Shaw, Gary S., Schild-Poulter, Caroline
Publicado 2019

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

por Spratt, Donald E., Julio Martinez-Torres, R, Noh, Yeong J., Mercier, Pascal, Manczyk, Noah, Barber, Kathryn R., Aguirre, Jacob D., Burchell, Lynn, Purkiss, Andrew, Walden, Helen, Shaw, Gary S.
Publicado 2013

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

por Kumar, Atul, Aguirre, Jacob D, Condos, Tara EC, Martinez-Torres, R Julio, Chaugule, Viduth K, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Mercier, Pascal, Knebel, Axel, Spratt, Donald E, Barber, Kathryn R, Shaw, Gary S, Walden, Helen
Publicado 2015

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

por Tokarew, Jacqueline M., El-Kodsi, Daniel N., Lengacher, Nathalie A., Fehr, Travis K., Nguyen, Angela P., Shutinoski, Bojan, O’Nuallain, Brian, Jin, Ming, Khan, Jasmine M., Ng, Andy C. H., Li, Juan, Jiang, Qiubo, Zhang, Mei, Wang, Liqun, Sengupta, Rajib, Barber, Kathryn R., Tran, An, Im, Doo Soon, Callaghan, Steve, Park, David S., Zandee, Stephanie, Dong, Xiajun, Scherzer, Clemens R., Prat, Alexandre, Tsai, Eve C., Takanashi, Masashi, Hattori, Nobutaka, Chan, Jennifer A., Zecca, Luigi, West, Andrew B., Holmgren, Arne, Puente, Lawrence, Shaw, Gary S., Toth, Gergely, Woulfe, John M., Taylor, Peggy, Tomlinson, Julianna J., Schlossmacher, Michael G.
Publicado 2021