IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors

por Hombach, Andreas, Barden, Markus, Hannappel, Lisa, Chmielewski, Markus, Rappl, Gunter, Sachinidis, Agapios, Abken, Hinrich
Publicado 2022

CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop

por Harrer, Dennis Christoph, Schenkel, Charlotte, Bezler, Valerie, Kaljanac, Marcell, Hartley, Jordan, Barden, Markus, Pan, Hong, Holzinger, Astrid, Herr, Wolfgang, Abken, Hinrich
Publicado 2022

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation

por Barden, Markus, Holzinger, Astrid, Velas, Lukas, Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György, Schütz, Gerhard J., Hombach, Andreas A., Abken, Hinrich
Publicado 2023