Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

por Bauzon, Maxine, Drake, Penelope M., Barfield, Robyn M., Cornali, Brandon M., Rupniewski, Igor, Rabuka, David
Publicado 2019

Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag**

por Hudak, Jason E, Barfield, Robyn M, de Hart, Gregory W, Grob, Patricia, Nogales, Eva, Bertozzi, Carolyn R, Rabuka, David
Publicado 2012

Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

por Linz, Thomas, Yeo, Dominick, Hong, Qiuting, Zmolek, Wesley, McFarland, Jesse, Barfield, Robyn M., Haskins, William E., Rabuka, David
Publicado 2018

Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)

por York, Dona, Baker, Jeanne, Holder, Patrick G., Jones, Lesley C., Drake, Penelope M., Barfield, Robyn M., Bleck, Gregory T., Rabuka, David
Publicado 2016

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion

por Holder, Patrick G., Jones, Lesley C., Drake, Penelope M., Barfield, Robyn M., Bañas, Stefanie, de Hart, Gregory W., Baker, Jeanne, Rabuka, David
Publicado 2015

Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions

por Huang, Betty C. B., Kim, Yun Cheol, Bañas, Stefanie, Barfield, Robyn M., Drake, Penelope M., Rupniewski, Igor, Haskins, William E., Rabuka, David
Publicado 2018

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

por Harel, Efrat T., Drake, Penelope M., Barfield, Robyn M., Lui, Irene, Farr-Jones, Shauna, Van’t Veer, Laura, Gartner, Zev J., Green, Evan M., Lourenço, André Luiz, Cheng, Yifan, Hann, Byron C., Rabuka, David, Craik, Charles S.
Publicado 2019

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

por Drake, Penelope M., Albers, Aaron E., Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M., Bhat, Abhijit S., de Hart, Gregory W., Garofalo, Albert W., Holder, Patrick, Jones, Lesley C., Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David
Publicado 2014