Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities

por Pechtl, Isabell C., Kavanagh, David, Mcintosh, Nicola, Harris, Claire L., Barlow, Paul N.
Publicado 2011

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation

por Soares, Dinesh C., Barlow, Paul N., Newbery, Helen J., Porteous, David J., Abbott, Catherine M.
Publicado 2009

Energetics of a protein disorder–order transition in small molecule recognition

por Mendoza-Martinez, Cesar, Papadourakis, Michail, Llabrés, Salomé, Gupta, Arun A., Barlow, Paul N., Michel, Julien
Publicado 2022

Structure of Complement C3(H(2)O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

por Chen, Zhuo A., Pellarin, Riccardo, Fischer, Lutz, Sali, Andrej, Nilges, Michael, Barlow, Paul N., Rappsilber, Juri
Publicado 2016

An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

por Biggs, Robyn M., Makou, Elisavet, Lauder, Scott, Herbert, Andrew P., Barlow, Paul N., Katti, Suresh K.
Publicado 2022

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

por Herbert, Andrew P., Makou, Elisavet, Chen, Zhuo A., Kerr, Heather, Richards, Anna, Rappsilber, Juri, Barlow, Paul N.
Publicado 2015

Annexin-II, DNA, and Histones Serve as Factor H Ligands on the Surface of Apoptotic Cells

por Leffler, Jonatan, Herbert, Andrew P., Norström, Eva, Schmidt, Christoph Q., Barlow, Paul N., Blom, Anna M., Martin, Myriam
Publicado 2010

Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

por Makou, Elisavet, Bailey, Richard G., Johnston, Heather, Parkin, John D., Hulme, Alison N., Hähner, Georg, Barlow, Paul N.
Publicado 2019

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface–selective regulation of complement activation

por Kerr, Heather, Wong, Edwin, Makou, Elisavet, Yang, Yi, Marchbank, Kevin, Kavanagh, David, Richards, Anna, Herbert, Andrew P., Barlow, Paul N.
Publicado 2017

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations

por Hocking, Henry G., Herbert, Andrew P., Kavanagh, David, Soares, Dinesh C., Ferreira, Viviana P., Pangburn, Michael K., Uhrín, Dusan, Barlow, Paul N.
Publicado 2008

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14(+) human monocytes into immunosuppressive macrophages

por Smolag, Karolina I., Mueni, Christine M., Leandersson, Karin, Jirström, Karin, Hagerling, Catharina, Mörgelin, Matthias, Barlow, Paul N., Martin, Myriam, Blom, Anna M.
Publicado 2020

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

por Makou, Elisavet, Mertens, Haydyn D.T., Maciejewski, Mateusz, Soares, Dinesh C., Matis, Ilias, Schmidt, Christoph Q., Herbert, Andrew P., Svergun, Dmitri I., Barlow, Paul N.
Publicado 2012

The Sushi Domains of Secreted GABA(B1) Isoforms Selectively Impair GABA(B) Heteroreceptor Function

por Tiao, Jim Y., Bradaia, Amyaouch, Biermann, Barbara, Kaupmann, Klemens, Metz, Michaela, Haller, Corinne, Rolink, Antonius G., Pless, Elin, Barlow, Paul N., Gassmann, Martin, Bettler, Bernhard
Publicado 2008

The Central Portion of Factor H (Modules 10–15) Is Compact and Contains a Structurally Deviant CCP Module

por Schmidt, Christoph Q., Herbert, Andrew P., Mertens, Haydyn D.T., Guariento, Mara, Soares, Dinesh C., Uhrin, Dusan, Rowe, Arthur J., Svergun, Dmitri I., Barlow, Paul N.
Publicado 2010

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

por Royer, Barbara, Soares, Dinesh C, Barlow, Paul N, Bontrop, Ronald E, Roll, Patrice, Robaglia-Schlupp, Andrée, Blancher, Antoine, Levasseur, Anthony, Cau, Pierre, Pontarotti, Pierre, Szepetowski, Pierre
Publicado 2007

Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)

por Morgan, Hugh P., Mertens, Haydyn D. T., Guariento, Mara, Schmidt, Christoph Q., Soares, Dinesh C., Svergun, Dmitri I., Herbert, Andrew P., Barlow, Paul N., Hannan, Jonathan P.
Publicado 2012

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

por Tetteh-Quarcoo, Patience B., Schmidt, Christoph Q., Tham, Wai-Hong, Hauhart, Richard, Mertens, Haydyn D. T., Rowe, Arthur, Atkinson, John P., Cowman, Alan F., Rowe, J. Alexandra, Barlow, Paul N.
Publicado 2012

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

por Smith-Jackson, Kate, Yang, Yi, Denton, Harriet, Pappworth, Isabel Y., Cooke, Katie, Barlow, Paul N., Atkinson, John P., Liszewski, M. Kathryn, Pickering, Matthew C., Kavanagh, David, Cook, H. Terence, Marchbank, Kevin J.
Publicado 2019

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

por Juárez-Jiménez, Jordi, Gupta, Arun A., Karunanithy, Gogulan, Mey, Antonia S. J. S., Georgiou, Charis, Ioannidis, Harris, De Simone, Alessio, Barlow, Paul N., Hulme, Alison N., Walkinshaw, Malcolm D., Baldwin, Andrew J., Michel, Julien
Publicado 2020

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

por Kerr, Heather, Herbert, Andrew P., Makou, Elisavet, Abramczyk, Dariusz, Malik, Talat H., Lomax-Browne, Hannah, Yang, Yi, Pappworth, Isabel Y., Denton, Harriet, Richards, Anna, Marchbank, Kevin J., Pickering, Matthew C., Barlow, Paul N.
Publicado 2021