TLR8: No gain, no pain

por Barrat, Franck J.
Publicado 2018

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

por Guiducci, Cristiana, Tripodo, Claudio, Gong, Mei, Sangaletti, Sabina, Colombo, Mario P., Coffman, Robert L., Barrat, Franck J.
Publicado 2010

TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells

por Youness, Ali, Cenac, Claire, Faz-López, Berenice, Grunenwald, Solange, Barrat, Franck J., Chaumeil, Julie, Mejía, José Enrique, Guéry, Jean-Charles
Publicado 2023

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

por Barrat, Franck J., Meeker, Thea, Gregorio, Josh, Chan, Jean H., Uematsu, Satoshi, Akira, Shizuo, Chang, Bonnie, Duramad, Omar, Coffman, Robert L.
Publicado 2005

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

por Guiducci, Cristiana, Ghirelli, Cristina, Marloie-Provost, Marie-Annick, Matray, Tracy, Coffman, Robert L., Liu, Yong-Jun, Barrat, Franck J., Soumelis, Vassili
Publicado 2008

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

por Ganguly, Dipyaman, Chamilos, Georgios, Lande, Roberto, Gregorio, Josh, Meller, Stephan, Facchinetti, Valeria, Homey, Bernhard, Barrat, Franck J., Zal, Tomasz, Gilliet, Michel
Publicado 2009

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

por Guiducci, Cristiana, Ott, Gary, Chan, Jean H., Damon, Emily, Calacsan, Carlo, Matray, Tracy, Lee, Kyung-Dall, Coffman, Robert L., Barrat, Franck J.
Publicado 2006

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

por Kader, Muhamuda, Smith, Amanda P., Guiducci, Cristiana, Wonderlich, Elizabeth R., Normolle, Daniel, Watkins, Simon C., Barrat, Franck J., Barratt-Boyes, Simon M.
Publicado 2013

Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation

por Du, Yong, Ah Kioon, Marie Dominique, Laurent, Paoline, Chaudhary, Vidyanath, Pierides, Michael, Yang, Chao, Oliver, David, Ivashkiv, Lionel B., Barrat, Franck J.
Publicado 2022

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

por Yang, Chao, Bachu, Mahesh, Du, Yong, Brauner, Caroline, Yuan, Ruoxi, Ah Kioon, Marie Dominique, Chesi, Giancarlo, Barrat, Franck J., Ivashkiv, Lionel B.
Publicado 2022

A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production

por Neighbors, Margaret, Xu, Xiuling, Barrat, Franck J., Ruuls, Sigrid R., Churakova, Tatyana, Debets, Reno, Bazan, J. Fernando, Kastelein, Robert A., Abrams, John S., O'Garra, Anne
Publicado 2001

RNA recognition by human TLR8 can lead to autoimmune inflammation

por Guiducci, Cristiana, Gong, Mei, Cepika, Alma-Martina, Xu, Zhaohui, Tripodo, Claudio, Bennett, Lynda, Crain, Chad, Quartier, Pierre, Cush, John J., Pascual, Virginia, Coffman, Robert L., Barrat, Franck J.
Publicado 2013

In Vitro Generation of Interleukin 10–producing Regulatory CD4(+) T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines...

por Barrat, Franck J., Cua, Daniel J., Boonstra, André, Richards, David F., Crain, Chad, Savelkoul, Huub F., de Waal-Malefyt, René, Coffman, Robert L., Hawrylowicz, Catherine M., O'Garra, Anne
Publicado 2002

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

por Laurent, Paôline, Yang, Chao, Rendeiro, André F., Nilsson-Payant, Benjamin E., Carrau, Lucia, Chandar, Vasuretha, Bram, Yaron, tenOever, Benjamin R., Elemento, Olivier, Ivashkiv, Lionel B., Schwartz, Robert E., Barrat, Franck J.
Publicado 2022

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

por Chaudhary, Vidyanath, Ah Kioon, Marie Dominique, Hwang, Sung-Min, Mishra, Bikash, Lakin, Kimberly, Kirou, Kyriakos A., Zhang-Sun, Jeffrey, Wiseman, R. Luke, Spiera, Robert F., Crow, Mary K., Gordon, Jessica K., Cubillos-Ruiz, Juan R., Barrat, Franck J.
Publicado 2022

Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice

por Chensue, Stephen W., Lukacs, Nicholas W., Yang, Tong-Yuan, Shang, Xiaozhou, Frait, Kirsten A., Kunkel, Steven L., Kung, Ted, Wiekowski, Maria T., Hedrick, Joseph A., Cook, Donald N., Zingoni, Alessandra, Narula, Satwant K., Zlotnik, Albert, Barrat, Franck J., O'Garra, Anne, Napolitano, Monica, Lira, Sergio A.
Publicado 2001

Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

por Yang, Kun, Puel, Anne, Zhang, Shenying, Eidenschenk, Céline, Ku, Cheng-Lung, Casrouge, Armanda, Picard, Capucine, von Bernuth, Horst, Senechal, Brigitte, Plancoulaine, Sabine, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Maródi, László, Davidson, Donald, Speert, David, Roifman, Chaim, Garty, Ben-Zion, Ozinsky, Adrian, Barrat, Franck J., Coffman, Robert L., Miller, Richard L., Li, Xiaoxia, Lebon, Pierre, Rodriguez-Gallego, Carlos, Chapel, Helen, Geissmann, Frédéric, Jouanguy, Emmanuelle, Casanova, Jean-Laurent
Publicado 2005

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

por Ku, Cheng-Lung, von Bernuth, Horst, Picard, Capucine, Zhang, Shen-Ying, Chang, Huey-Hsuan, Yang, Kun, Chrabieh, Maya, Issekutz, Andrew C., Cunningham, Coleen K., Gallin, John, Holland, Steven M., Roifman, Chaim, Ehl, Stephan, Smart, Joanne, Tang, Mimi, Barrat, Franck J., Levy, Ofer, McDonald, Douglas, Day-Good, Noorbibi K., Miller, Richard, Takada, Hidetoshi, Hara, Toshiro, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Speert, David, Sanlaville, Damien, Li, Xiaoxia, Geissmann, Frédéric, Vivier, Eric, Maródi, László, Garty, Ben-Zion, Chapel, Helen, Rodriguez-Gallego, Carlos, Bossuyt, Xavier, Abel, Laurent, Puel, Anne, Casanova, Jean-Laurent
Publicado 2007