Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A(2A) Receptor

por Pedreira, Júlia Galvez Bulhões, Silva, Rafaela Ribeiro, Noël, François G., Barreiro, Eliezer J.
Publicado 2021

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

por Nascimento-Júnior, Nailton M., Kümmerle, Arthur E., Barreiro, Eliezer J., Fraga, Carlos A. M.
Publicado 2011

Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension

por Alencar, Allan K. N., Montes, Guilherme C., Barreiro, Eliezer J., Sudo, Roberto T., Zapata-Sudo, Gisele
Publicado 2017

Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives

por Lopes, Alexandra Basilio, Miguez, Eduardo, Kümmerle, Arthur Eugen, Rumjanek, Victor Marcos, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.
Publicado 2013

1-Methyl-7-(4-nitro­phen­yl)-3-phenyl­pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione

por Sabino, Jose R., Oliveira, Cecília M. A., Fraga, Carlos A. M., Barreiro, Eliezer J., de Oliveira, Valéria, Menegatti, Ricardo
Publicado 2008

Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models

por Colodette, Natalie M., Franco, Lucas S., Maia, Rodolfo C., Fokoue, Harold H., Sant’Anna, Carlos Mauricio R., Barreiro, Eliezer J.
Publicado 2020

3-Aminothiophene-2-Acylhydrazones: Non-Toxic, Analgesic and Anti-Inflammatory Lead-Candidates

por da Silva, Yolanda Karla Cupertino, Reyes, Christian Tadeo Moreno, Rivera, Gildardo, Alves, Marina Amaral, Barreiro, Eliezer J., Moreira, Magna Suzana Alexandre, Lima, Lídia Moreira
Publicado 2014

Carbamoyl-N-aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate

por Alves, Marina A., de Queiroz, Aline C., Leite, Anderson Brandão, Martins, Felipe T., Doriguetto, Antonio C., Barreiro, Eliezer J., Alexandre-Moreira, Magna S., Lima, Lídia M.
Publicado 2020

Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies

por Lacerda, Renata B., Sales, Natália M., da Silva, Leandro L., Tesch, Roberta, Miranda, Ana Luisa P., Barreiro, Eliezer J., Fernandes, Patricia D., Fraga, Carlos A. M.
Publicado 2014

Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A(2A) receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats

por Alencar, Allan K., Carvalho, Fábio I., Silva, Ananssa M., Martinez, Sabrina T., Calasans-Maia, Jorge A., Fraga, Carlos M., Barreiro, Eliezer J., Zapata-Sudo, Gisele, Sudo, Roberto T.
Publicado 2018

Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones

por Guedes, Jéssica de Siqueira, Carneiro, Teiliane Rodrigues, Pinheiro, Pedro de Sena Murteira, Fraga, Carlos Alberto Manssour, Sant′Anna, Carlos Mauricio R., Barreiro, Eliezer J., Lima, Lídia Moreira
Publicado 2022

Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production

por Lacerda, Renata B., da Silva, Leandro L., de Lima, Cleverton K. F., Miguez, Eduardo, Miranda, Ana Luisa P., Laufer, Stefan A., Barreiro, Eliezer J., Fraga, Carlos A. M.
Publicado 2012

Synthesis and Pharmacological Evaluation of Novel Phenyl Sulfonamide Derivatives Designed as Modulators of Pulmonary Inflammatory Response

por de Castro Barbosa, Maria Letícia, Ramos, Thiago José Figueira, de Arantes, Ana Carolina Santos, Martins, Marco Aurélio, Silva, Patrícia Machado Rodrigues e, Barreiro, Eliezer J., Lima, Lídia Moreira
Publicado 2012

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Sign...

por Silva, Rafaela R., Parreiras-e-Silva, Lucas T., Pompeu, Thais E.T., Duarte, Diego A., Fraga, Carlos A.M., Barreiro, Eliezer J., Menegatti, Ricardo, Costa-Neto, Claudio M., Noël, François
Publicado 2019

Adenosine A(2A) receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

por da Silva, Jaqueline S, Gabriel-Costa, Daniele, Sudo, Roberto T, Wang, Hao, Groban, Leanne, Ferraz, Emanuele B, Nascimento, José Hamilton M, Fraga, Carlos Alberto M, Barreiro, Eliezer J, Zapata-Sudo, Gisele
Publicado 2017

Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H(2)LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H(2)LASSBio-1064) and Their Zi...

por Júnior, Walfrido Bispo, Alexandre-Moreira, Magna S., Alves, Marina A., Perez-Rebolledo, Anayive, Parrilha, Gabrieli L., Castellano, Eduardo E., Piro, Oscar E., Barreiro, Eliezer J., Lima, Lídia Moreira, Beraldo, Heloisa
Publicado 2011

A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives

por do Amaral, Daniel Nascimento, Lategahn, Jonas, Fokoue, Harold Hilarion, da Silva, Eduardo Miguez Bastos, Sant’Anna, Carlos Mauricio R., Rauh, Daniel, Barreiro, Eliezer J., Laufer, Stefan, Lima, Lidia Moreira
Publicado 2019

Comparative chemical and biological hydrolytic stability of homologous esters and isosteres

por de Souza, Hygor M. R., Guedes, Jéssica S., Freitas, Rosana H. C. N., Gelves, Luis G. V., Fokoue, Harold H., Sant’Anna, Carlos Mauricio R., Barreiro, Eliezer J., Lima, Lidia M.
Publicado 2022

Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues

por de Miranda, Amanda Silva, Júnior, Walfrido Bispo, da Silva, Yolanda Karla Cupertino, Alexandre-Moreira, Magna Suzana, Castro, Rosane de Paula, Sabino, José Ricardo, Lião, Luciano Morais, Lima, Lídia Moreira, Barreiro, Eliezer J.
Publicado 2012

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

por Lima, Lidia Moreira, da Silva, Tiago Fernandes, da Silva Monteiro, Carlos Eduardo, Aparecida-Silva, Cristiane, Bispo Júnior, Walfrido, de Queiroz, Aline Cavalcanti, Alexandre-Moreira, Magna Suzana, Zapata-Sudo, Gisele, Barreiro, Eliezer J.
Publicado 2021