Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

por Liberante, Fabio Giuseppe, Lappin, Katrina, Barros, Eliana M., Vohhodina, Jekaterina, Grebien, Florian, Savage, Kienan I., Mills, Kenneth Ian
Publicado 2019

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

por Vohhodina, Jekaterina, Barros, Eliana M., Savage, Abigail L., Liberante, Fabio G., Manti, Lorenzo, Bankhead, Peter, Cosgrove, Nicola, Madden, Angelina F., Harkin, D. Paul, Savage, Kienan I.
Publicado 2017

NF-κB is a Critical Mediator of BRCA1 induced Chemoresistance

por Harte, Mary T, Gorski, Julia J, Savage, Kienan I, Purcell, James W, Barros, Eliana M, Burn, Philip M, McFarlane, Cheryl, Mullan, Paul B, Kennedy, Richard D, Perkins, Neil D, Harkin, D Paul
Publicado 2013

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

por Lappin, Katrina M., Barros, Eliana M., Jhujh, Satpal S., Irwin, Gareth W., McMillan, Hayley, Liberante, Fabio G., Latimer, Cheryl, La Bonte, Melissa J., Mills, Ken I., Harkin, D. Paul, Stewart, Grant S., Savage, Kienan I.
Publicado 2022

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

por Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul
Publicado 2014