A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

por Stiborová, Marie, Bárta, František, Levová, Kateřina, Hodek, Petr, Schmeiser, Heinz H., Arlt, Volker M., Martínek, Václav
Publicado 2015

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1

por Milichovský, Jan, Bárta, František, Schmeiser, Heinz H., Arlt, Volker M., Frei, Eva, Stiborová, Marie, Martínek, Václav
Publicado 2016

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches

por Martínek, Václav, Bárta, František, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie
Publicado 2017

Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats

por Bárta, František, Dedíková, Alena, Bebová, Michaela, Dušková, Šárka, Mráz, Jaroslav, Schmeiser, Heinz H., Arlt, Volker M., Hodek, Petr, Stiborová, Marie
Publicado 2021

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

por Dračínská, Helena, Bárta, František, Levová, Kateřina, Hudecová, Alena, Moserová, Michaela, Schmeiser, Heinz H., Kopka, Klaus, Frei, Eva, Arlt, Volker M., Stiborová, Marie
Publicado 2016

Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice

por Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Publicado 2018

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

por Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Publicado 2016