Myelotoxicity of Temozolomide Treatment in Patients with Glioblastoma Is It Time for a More Mechanistic Approach?

por Said, Medhat M., Broen, Martinus P. G., Swart, Eleonora L., Bartelink, Imke H., Kouwenhoven, Mathilde C. M.
Publicado 2023

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer

por Jafarnejad, Mohammad, Gong, Chang, Gabrielson, Edward, Bartelink, Imke H., Vicini, Paolo, Wang, Bing, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.
Publicado 2019

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

por Milberg, Oleg, Gong, Chang, Jafarnejad, Mohammad, Bartelink, Imke H., Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.
Publicado 2019

Pharmacological Optimization of PSMA-Based Radioligand Therapy

por van der Gaag, Suzanne, Bartelink, Imke H., Vis, André N., Burchell, George L., Oprea-Lager, Daniela E., Hendrikse, Harry
Publicado 2022

In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model

por Wang, Hanwen, Milberg, Oleg, Bartelink, Imke H., Vicini, Paolo, Wang, Bing, Narwal, Rajesh, Roskos, Lorin, Santa-Maria, Cesar A., Popel, Aleksander S.
Publicado 2019

Quantitative Characterization of CD8+ T Cell Clustering and Spatial Heterogeneity in Solid Tumors

por Gong, Chang, Anders, Robert A., Zhu, Qingfeng, Taube, Janis M., Green, Benjamin, Cheng, Wenting, Bartelink, Imke H., Vicini, Paolo, Wang, Bing, Popel, Aleksander S.
Publicado 2019

Relationship between Biodistribution and Tracer Kinetics of (11)C-Erlotinib, (18)F-Afatinib and (11)C-Osimertinib and Image Quality Evaluation Using Pharmacokinetic/Pharmacodynamic...

por van de Stadt, Eveline Annette, Yaqub, Maqsood, Schuit, Robert C., Bartelink, Imke H., Leeuwerik, Anke F., Schwarte, Lothar A., de Langen, Adrianus J., Hendrikse, Harry, Bahce, Idris
Publicado 2022

Estimation of glomerular filtration rate for drug dosing in patients with very high or low body mass index

por Donker, Erik M., Bet, Pierre, Nurmohamed, Azam, Serné, Erik, Burchell, George Louis, Friedman, Allon N., Bouquegneau, Antoine, Lemoine, Sandrine, Ebert, Natalie, Cirillo, Massimo, van Agtmael, Michiel A., Bartelink, Imke H.
Publicado 2022

Intraoperative Visualization and Treatment of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients Using Contrast-Enhanced Ultrasound Sialendoscopy (CEUSS)

por Karagozoglu, K. Hakki, Mahraoui, Anissa, Bot, Joseph C. J., Cha, Seunghee, Ho, Jean-Pierre T. F., Helder, Marco N., Brand, Henk S., Bartelink, Imke H., Vissink, Arjan, Weisman, Gary A., Jager, Derk Hendrik Jan
Publicado 2023

Optimizing Antiviral Dosing for HSV and CMV Treatment in Immunocompromised Patients

por Huntjens, Daan W., Dijkstra, Jacob A., Verwiel, Lisanne N., Slijkhuis, Mirjam, Elbers, Paul, Welkers, Matthijs R. A., Veldkamp, Agnes I., Kuijvenhoven, Marianne A., de Leeuw, David C., Abdullah-Koolmees, Heshu, Kuipers, Maria T., Bartelink, Imke H.
Publicado 2023

Response and Adherence to Nilotinib in Daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotinib

por Boons, Christel C. L. M., Timmers, Lonneke, Janssen, Jeroen J. W. M., Westerweel, Peter E., Blijlevens, Nicole M. A., Smit, Willem M., Bartelink, Imke H., Wilschut, Janneke A., Swart, Eleonora L., Hendrikse, N. Harry, Hugtenburg, Jacqueline G.
Publicado 2020

Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19

por Baalbaki, Nadia, Duijvelaar, Erik, Said, Medhat M., Schippers, Job, Bet, Pierre M., Twisk, Jos, Fritchley, Sarah, Longo, Cristina, Mahmoud, Kazien, Maitland-van der Zee, Anke H., Bogaard, Harm Jan, Swart, Eleonora L., Aman, Jurjan, Bartelink, Imke H.
Publicado 2023

Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study

por Bartelink, Imke H., Bet, Pierre M., Widmer, Nicolas, Guidi, Monia, Duijvelaar, Erik, Grob, Bram, Honeywell, Richard, Evelo, Amanda, Tielbeek, Ivo P. E., Snape, Sue D., Hamer, Henrike, Decosterd, Laurent A., Jan Bogaard, Harm, Aman, Jurjan, Swart, Eleonora L.
Publicado 2021

Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle

por Bartelink, Imke H., Jones, Ella F., Shahidi‐Latham, Sheerin K., Lee, Pei Rong Evelyn, Zheng, Yanan, Vicini, Paolo, van ‘t Veer, Laura, Wolf, Denise, Iagaru, Andrei, Kroetz, Deanna L., Prideaux, Brendan, Cilliers, Cornelius, Thurber, Greg M., Wimana, Zena, Gebhart, Geraldine
Publicado 2018

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with...

por Atmowihardjo, Leila, Schippers, Job R., Bartelink, Imke H., Bet, Pierre M., van Rein, Nienke, Purdy, Keith, Cavalla, David, Comberiati, Valérie, McElroy, Andrew, Snape, Sue D., Bogaard, Harm Jan, Heunks, Leo, Juffermans, Nicole, Schultz, Marcus, Tuinman, Pieter R., Bos, Lieuwe D. J., Aman, Jurjan
Publicado 2022

Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0–1 non-small cell lung cancer: the INCREASE trial

por Dickhoff, Chris, Senan, Suresh, Schneiders, Famke L., Veltman, Joris, Hashemi, Sayed, Daniels, Johannes M. A., Fransen, Marieke, Heineman, David J., Radonic, Teodora, van de Ven, Peter M., Bartelink, Imke H., Meijboom, Lilian J., Garcia-Vallejo, Juan J., Oprea-Lager, Daniela E., de Gruijl, Tanja D., Bahce, Idris
Publicado 2020

GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study

por Ansari, Marc, Curtis, Patricia Huezo-Diaz, Uppugunduri, Chakradhara Rao S., Rezgui, Mohammed Aziz, Nava, Tiago, Mlakar, Vid, Lesne, Laurence, Théoret, Yves, Chalandon, Yves, Dupuis, Lee L., Schechter, Tao, Bartelink, Imke H., Boelens, Jaap J., Bredius, Robbert, Dalle, Jean-Hugues, Azarnoush, Saba, Sedlacek, Petr, Lewis, Victor, Champagne, Martin, Peters, Christina, Bittencourt, Henrique, Krajinovic, Maja
Publicado 2017

Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial

por Atmowihardjo, Leila N., Schippers, Job R., Duijvelaar, Erik, Bartelink, Imke H., Bet, Pierre M., Swart, Noortje E. L., van Rein, Nienke, Purdy, Keith, Cavalla, David, McElroy, Andrew, Fritchley, Sarah, Vonk Noordegraaf, Anton, Endeman, Henrik, van Velzen, Patricia, Koopmans, Matty, Bogaard, Harm Jan, Heunks, Leo, Juffermans, Nicole, Schultz, Marcus J., Tuinman, Pieter R., Bos, Lieuwe D. J., Aman, Jurjan
Publicado 2023

Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

por Bartelink, Imke H., Prideaux, Brendan, Krings, Gregor, Wilmes, Lisa, Lee, Pei Rong Evelyn, Bo, Pan, Hann, Byron, Coppé, Jean-Philippe, Heditsian, Diane, Swigart-Brown, Lamorna, Jones, Ella F., Magnitsky, Sergey, Keizer, Ron J, de Vries, Niels, Rosing, Hilde, Pawlowska, Nela, Thomas, Scott, Dhawan, Mallika, Aggarwal, Rahul, Munster, Pamela N., Esserman, Laura J., Ruan, Weiming, Wu, Alan H. B., Yee, Douglas, Dartois, Véronique, Savic, Radojka M., Wolf, Denise M., van ’t Veer, Laura
Publicado 2017

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

por Aman, Jurjan, Duijvelaar, Erik, Botros, Liza, Kianzad, Azar, Schippers, Job R, Smeele, Patrick J, Azhang, Sara, Bartelink, Imke H, Bayoumy, Ahmed A, Bet, Pierre M, Boersma, Wim, Bonta, Peter I, Boomars, Karin A T, Bos, Lieuwe D J, van Bragt, Job J M H, Braunstahl, Gert-Jan, Celant, Lucas R, Eger, Katrien A B, Geelhoed, J J Miranda, van Glabbeek, Yurika L E, Grotjohan, Hans P, Hagens, Laura A, Happe, Chris M, Hazes, Boaz D, Heunks, Leo M A, van den Heuvel, Michel, Hoefsloot, Wouter, Hoek, Rianne J A, Hoekstra, Romke, Hofstee, Herman M A, Juffermans, Nicole P, Kemper, E Marleen, Kos, Renate, Kunst, Peter W A, Lammers, Ariana, van der Lee, Ivo, van der Lee, E Laurien, Maitland-van der Zee, Anke-Hilse, Mau Asam, Pearl F M, Mieras, Adinda, Muller, Mirte, Neefjes, Elisabeth C W, Nossent, Esther J, Oswald, Laurien M A, Overbeek, Maria J, Pamplona, Carolina C, Paternotte, Nienke, Pronk, Niels, de Raaf, Michiel A, van Raaij, Bas F M, Reijrink, Merlijn, Schultz, Marcus J, Serpa Neto, Ary, Slob, Elise M A, Smeenk, Frank W J M, Smit, Marry R, Smits, A Josien, Stalenhoef, Janneke E, Tuinman, Pieter R, Vanhove, Arthur L E M, Wessels, Jeroen N, van Wezenbeek, Jessie C C, Vonk Noordegraaf, Anton, de Man, Frances S, Bogaard, Harm J
Publicado 2021