Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

por Barthélemy, Nicolas R., Horie, Kanta, Sato, Chihiro, Bateman, Randall J.
Publicado 2020

Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios

por Janelidze, Shorena, Barthélemy, Nicolas R., He, Yingxin, Bateman, Randall J., Hansson, Oskar
Publicado 2023

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzh...

por Barthélemy, Nicolas R., Mallipeddi, Nipun, Moiseyev, Paul, Sato, Chihiro, Bateman, Randall J.
Publicado 2019

Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry

por Bros, Pauline, Vialaret, Jérôme, Barthelemy, Nicolas, Delatour, Vincent, Gabelle, Audrey, Lehmann, Sylvain, Hirtz, Christophe
Publicado 2015

A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in own...

por Comblain, Fanny, Barthélémy, Nicolas, Lefèbvre, Michael, Schwartz, Cédric, Lesponne, Isabelle, Serisier, Samuel, Feugier, Alexandre, Balligand, Marc, Henrotin, Yves
Publicado 2017

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

por Barthélemy, Nicolas R., Bateman, Randall J., Hirtz, Christophe, Marin, Philippe, Becher, François, Sato, Chihiro, Gabelle, Audrey, Lehmann, Sylvain
Publicado 2020

Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain

por Horie, Kanta, Barthélemy, Nicolas R., Mallipeddi, Nipun, Li, Yan, Franklin, Erin E., Perrin, Richard J., Bateman, Randall J., Sato, Chihiro
Publicado 2020

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated

por Barthélemy, Nicolas R., Toth, Balazs, Manser, Paul T., Sanabria-Bohórquez, Sandra, Teng, Edmond, Keeley, Michael, Bateman, Randall J., Weimer, Robby M., Wildsmith, Kristin R.
Publicado 2022

A map of neurofilament light chain species in brain and cerebrospinal fluid and alterations in Alzheimer’s disease

por Budelier, Melissa M., He, Yingxin, Barthelemy, Nicolas R., Jiang, Hong, Li, Yan, Park, Ethan, Henson, Rachel L., Schindler, Suzanne E., Holtzman, David M., Bateman, Randall J.
Publicado 2022

Protein production is an early biomarker for RNA‐targeted therapies

por Self, Wade K., Schoch, Kathleen M., Alex, Jacob, Barthélemy, Nicolas, Bollinger, James G., Sato, Chihiro, Cole, Tracy, Kordasiewicz, Holly B., Swayze, Eric, Bateman, Randall J., Miller, Timothy M.
Publicado 2018

MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology

por Sato, Chihiro, Mallipeddi, Nipun, Ghoshal, Nupur, Wright, Brenton A., Day, Gregory S., Davis, Albert A., Kim, Albert H., Zipfel, Gregory J., Bateman, Randall J., Gabelle, Audrey, Barthélemy, Nicolas R.
Publicado 2021

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease

por Janelidze, Shorena, Bali, Divya, Ashton, Nicholas J, Barthélemy, Nicolas R, Vanbrabant, Jeroen, Stoops, Erik, Vanmechelen, Eugeen, He, Yingxin, Dolado, Anna Orduña, Triana-Baltzer, Gallen, Pontecorvo, Michael J, Zetterberg, Henrik, Kolb, Hartmuth, Vandijck, Manu, Blennow, Kaj, Bateman, Randall J, Hansson, Oskar
Publicado 2022

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

por Bathla, Shveta, Datta, Dibyadeep, Liang, Feng, Barthelemy, Nicolas, Wiseman, Robyn, Slusher, Barbara S, Asher, Jennifer, Zeiss, Caroline, Ekanayake‐Alper, Dil, Holden, Daniel, Terwilliger, Gordon, Duque, Alvaro, Arellano, Jon, van Dyck, Christopher, Bateman, Randall J., Xie, Zhongcong, Nairn, Angus C., Arnsten, Amy F. T.
Publicado 2023

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

por Barthélemy, Nicolas R., Saef, Benjamin, Li, Yan, Gordon, Brian A., He, Yingxin, Horie, Kanta, Stomrud, Erik, Salvadó, Gemma, Janelidze, Shorena, Sato, Chihiro, Ovod, Vitaliy, Henson, Rachel L., Fagan, Anne M., Benzinger, Tammie L. S., Xiong, Chengjie, Morris, John C., Hansson, Oskar, Bateman, Randall J., Schindler, Suzanne E.
Publicado 2023

Novel CSF tau biomarkers can be used for disease staging of sporadic Alzheimer’s disease

por Salvadó, Gemma, Horie, Kanta, Barthélemy, Nicolas R., Vogel, Jacob W., Binette, Alexa Pichet, Chen, Charles D., Aschenbrenner, Andrew J, Gordon, Brian A., Benzinger, Tammie L.S., Holtzman, David M., Morris, John C., Palmqvist, Sebastian, Stomrud, Erik, Janelidze, Shorena, Ossenkoppele, Rik, Schindler, Suzanne E., Bateman, Randall J., Hansson, Oskar
Publicado 2023

CSF tau microtubule-binding region identifies pathological changes in primary tauopathies

por Horie, Kanta, Barthélemy, Nicolas R., Spina, Salvatore, VandeVrede, Lawren, He, Yingxin, Paterson, Ross W., Wright, Brenton A., Day, Gregory S., Davis, Albert A., Karch, Celeste M., Seeley, William W., Perrin, Richard J., Koppisetti, Rama K., Shaikh, Faris, Lago, Argentina Lario, Heuer, Hilary W., Ghoshal, Nupur, Gabelle, Audrey, Miller, Bruce L., Boxer, Adam L., Bateman, Randall J., Sato, Chihiro
Publicado 2022

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

por Horie, Kanta, Salvadó, Gemma, Barthélemy, Nicolas R., Janelidze, Shorena, Li, Yan, He, Yingxin, Saef, Benjamin, Chen, Charles D., Jiang, Hong, Strandberg, Olof, Pichet Binette, Alexa, Palmqvist, Sebastian, Sato, Chihiro, Sachdev, Pallavi, Koyama, Akihiko, Gordon, Brian A., Benzinger, Tammie L. S., Holtzman, David M., Morris, John C., Mattsson-Carlgren, Niklas, Stomrud, Erik, Ossenkoppele, Rik, Schindler, Suzanne E., Hansson, Oskar, Bateman, Randall J.
Publicado 2023

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease

por Strain, Jeremy F., Barthelemy, Nicolas, Horie, Kanta, Gordon, Brian A., Kilgore, Collin, Aschenbrenner, Andrew, Cruchaga, Carlos, Xiong, Chengjie, Joseph-Mathurin, Nelly, Hassenstab, Jason, Fagan, Anne M., Li, Yan, Karch, Celeste M., Perrin, Richard J., Berman, Sarah B., Chhatwal, Jasmeer P., Graff-Radford, Neill R., Mori, Hiroshi, Levin, Johannes, Noble, James M., Allegri, Ricardo, Schofield, Peter R., Marcus, Daniel S., Holtzman, David M., Morris, John C., Benzinger, Tammie L.S., McDade, Eric M., Bateman, Randall J., Ances, Beau M.
Publicado 2022

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

por Johnson, Erik C. B., Bian, Shijia, Haque, Rafi U., Carter, E. Kathleen, Watson, Caroline M., Gordon, Brian A., Ping, Lingyan, Duong, Duc M., Epstein, Michael P., McDade, Eric, Barthélemy, Nicolas R., Karch, Celeste M., Xiong, Chengjie, Cruchaga, Carlos, Perrin, Richard J., Wingo, Aliza P., Wingo, Thomas S., Chhatwal, Jasmeer P., Day, Gregory S., Noble, James M., Berman, Sarah B., Martins, Ralph, Graff-Radford, Neill R., Schofield, Peter R., Ikeuchi, Takeshi, Mori, Hiroshi, Levin, Johannes, Farlow, Martin, Lah, James J., Haass, Christian, Jucker, Mathias, Morris, John C., Benzinger, Tammie L. S., Roberts, Blaine R., Bateman, Randall J., Fagan, Anne M., Seyfried, Nicholas T., Levey, Allan I.
Publicado 2023

Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease

por Schultz, Stephanie A., Shirzadi, Zahra, Schultz, Aaron P., Liu, Lei, Fitzpatrick, Colleen D., McDade, Eric, Barthelemy, Nicolas R., Renton, Alan, Esposito, Bianca, Joseph‐Mathurin, Nelly, Cruchaga, Carlos, Chen, Charles D., Goate, Alison, Allegri, Ricardo Francisco, Benzinger, Tammie L. S., Berman, Sarah, Chui, Helena C., Fagan, Anne M., Farlow, Martin R., Fox, Nick C., Gordon, Brian A., Day, Gregory S., Graff‐Radford, Neill R., Hassenstab, Jason J., Hanseeuw, Bernard J., Hofmann, Anna, Jack, Clifford R., Jucker, Mathias, Karch, Celeste M., Koeppe, Robert A., Lee, Jae‐Hong, Levey, Allan I., Levin, Johannes, Martins, Ralph N., Mori, Hiroshi, Morris, John C., Noble, James, Perrin, Richard J., Rosa‐Neto, Pedro, Salloway, Stephen P., Sanchez‐Valle, Raquel, Schofield, Peter R., Xiong, Chengjie, Johnson, Keith A., Bateman, Randall J., Sperling, Reisa A., Chhatwal, Jasmeer P.
Publicado 2023