Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling...

por Li, Rui, Barton, Hugh A.
Publicado 2017

A Multiscale, Mechanism-Driven, Dynamic Model for the Effects of 5α-Reductase Inhibition on Prostate Maintenance

por Zager, Michael G., Barton, Hugh A.
Publicado 2012

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.

por Clewell, Harvey J, Andersen, Melvin E, Barton, Hugh A
Publicado 2002

Assessing Susceptibility from Early-Life Exposure to Carcinogens

por Barton, Hugh A., Cogliano, V. James, Flowers, Lynn, Valcovic, Larry, Setzer, R. Woodrow, Woodruff, Tracey J.
Publicado 2005

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

por Woodhead, Jeffrey L., Yang, Kyunghee, Siler, Scott Q., Watkins, Paul B., Brouwer, Kim L. R., Barton, Hugh A., Howell, Brett A.
Publicado 2014

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D(2) Receptor Occupancy

por Johnson, Martin, Kozielska, Magdalena, Pilla Reddy, Venkatesh, Vermeulen, An, Barton, Hugh A., Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Publicado 2016

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

por Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert
Publicado 2019

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

por Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Publicado 2019

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment

por Tan, Yu-Mei, Barton, Hugh A., Boobis, Alan, Brunner, Rachel, Clewell, Harvey, Cope, Rhian, Dawson, Jeffrey, Domoradzki, Jeanne, Egeghy, Peter, Gulati, Pankaj, Ingle, Brandall, Kleinstreuer, Nicole, Lowe, Kelly, Lowit, Anna, Mendez, Elizabeth, Miller, David, Minucci, Jeffrey, Nguyen, James, Paini, Alicia, Perron, Monique, Phillips, Katherine, Qian, Hua, Ramanarayanan, Tharacad, Sewell, Fiona, Villanueva, Philip, Wambaugh, John, Embry, Michelle
Publicado 2021