Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

por Fuentes, Gloria, Scaltriti, Maurizio, Baselga, José, Verma, Chandra S
Publicado 2011

Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs

por Osmanbeyoglu, Hatice U., Toska, Eneda, Chan, Carmen, Baselga, José, Leslie, Christina S.
Publicado 2017

The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

por Grego-Bessa, Joaquim, Bloomekatz, Joshua, Castel, Pau, Omelchenko, Tatiana, Baselga, José, Anderson, Kathryn V
Publicado 2016

Treatment of older patients with HER2-positive metastatic breast cancer with pertuzumab, trastuzumab, and docetaxel: subgroup analyses from a randomized, double-blind, placebo-cont...

por Miles, David, Baselga, José, Amadori, Dino, Sunpaweravong, Patrapim, Semiglazov, Vladimir, Knott, Adam, Clark, Emma, Ross, Graham, Swain, Sandra M.
Publicado 2013

TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS

por Raina, Deepak, Uchida, Yasumitsu, Kharbanda, Akriti, Rajabi, Hasan, Panchamoorthy, Govind, Jin, Caining, Kharbanda, Surender, Scaltriti, Maurizio, Baselga, Jose, Kufe, Donald
Publicado 2013

Molecular Features and Survival Outcomes of the Intrinsic Subtypes Within HER2-Positive Breast Cancer

por Prat, Aleix, Carey, Lisa A., Adamo, Barbara, Vidal, Maria, Tabernero, Josep, Cortés, Javier, Parker, Joel S., Perou, Charles M., Baselga, José
Publicado 2014

Analysis and variability of TGFβ measurements in cancer patients with skeletal metastases

por O’Brien, Peter J, Ramanathan, Rajeev, Yingling, Jonathan M, Baselga, Jose, Rothenberg, Mace L, Carducci, Michael, Daly, Thomas, Adcock, Dorothy, Lahn, Michael
Publicado 2008

A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer

por Modi, Shanu, Saura, Cristina, Henderson, Charles, Lin, Nancy U., Mahtani, Reshma, Goddard, Jill, Rodenas, Eduardo, Hudis, Clifford, O’Shaughnessy, Joyce, Baselga, Jose
Publicado 2013

A phase 3 tRial comparing capecitabinE in combination with SorafenIb or pLacebo for treatment of locally advanced or metastatIc HER2-Negative breast CancEr (the RESILIENCE study):...

por Baselga, José, Costa, Frederico, Gomez, Henry, Hudis, Clifford A, Rapoport, Bernardo, Roche, Henri, Schwartzberg, Lee S, Petrenciuc, Oana, Shan, Minghua, Gradishar, William J
Publicado 2013

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

por Bago, Ruzica, Sommer, Eeva, Castel, Pau, Crafter, Claire, Bailey, Fiona P, Shpiro, Natalia, Baselga, José, Cross, Darren, Eyers, Patrick A, Alessi, Dario R
Publicado 2016

Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

por Chandarlapaty, Sarat, Scaltriti, Maurizio, Angelini, Pierdavide, Ye, Qing, Guzman, Marta, Hudis, Clifford A., Norton, Larry, Solit, David B., Arribas, Joaquin, Baselga, Jose, Rosen, Neal
Publicado 2009

Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment fr...

por Bonner, James A., Giralt, Jordi, Harari, Paul M., Baselga, Jose, Spencer, Sharon, Bell, Diana, Raben, David, Liu, Joyce, Schulten, Jeltje, Ang, Kian K., Rosenthal, David I.
Publicado 2016

Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR(+), HER2(−) advanced breast cancer: results from BOLERO-2

por Moynahan, Mary Ellen, Chen, David, He, Wei, Sung, Patricia, Samoila, Aliaksandra, You, Daoqi, Bhatt, Trusha, Patel, Parul, Ringeisen, Francois, Hortobagyi, Gabriel N, Baselga, Jose, Chandarlapaty, Sarat
Publicado 2017

PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

por Loi, Sherene, Michiels, Stefan, Baselga, Jose, Bartlett, John M. S., Singhal, Sandeep K., Sabine, Vicky S., Sims, Andrew H., Sahmoud, Tarek, Dixon, J. Michael, Piccart, Martine J., Sotiriou, Christos
Publicado 2013

Correction: PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

por Loi, Sherene, Michiels, Stefan, Baselga, Jose, Bartlett, John M. S., Singhal, Sandeep K., Sabine, Vicky S., Sims, Andrew H., Sahmoud, Tarek, Michael Dixon, J., Piccart, Martine J., Sotiriou, Christos
Publicado 2019

A Phase II Trial of Cabozantinib in Hormone Receptor‐Positive Breast Cancer with Bone Metastases

por Xu, Jing, Higgins, Michaela J., Tolaney, Sara M., Come, Steven E., Smith, Matthew R., Fornier, Monica, Mahmood, Umar, Baselga, Jose, Yeap, Beow Y., Chabner, Bruce A., Isakoff, Steven J.
Publicado 2020

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

por Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Publicado 2016

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

por Mizrachi, Aviram, Shamay, Yosi, Shah, Janki, Brook, Samuel, Soong, Joanne, Rajasekhar, Vinagolu K., Humm, John L., Healey, John H., Powell, Simon N., Baselga, José, Heller, Daniel A., Haimovitz-Friedman, Adriana, Scaltriti, Maurizio
Publicado 2017

Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study

por Kovacs, Richard J., Maldonado, Giuliana, Azaro, Analia, Fernández, Maria S., Romero, Federico L., Sepulveda-Sánchez, Juan M., Corretti, Mary, Carducci, Michael, Dolan, Melda, Gueorguieva, Ivelina, Cleverly, Ann L., Pillay, N. Sokalingum, Baselga, Jose, Lahn, Michael M.
Publicado 2014

Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy

por Choy, Edwin, Butrynski, James E, Harmon, David C, Morgan, Jeffrey A, George, Suzanne, Wagner, Andrew J, D’Adamo, David, Cote, Gregory M, Flamand, Yael, Benes, Cyril H, Haber, Daniel A, Baselga, Jose M, Demetri, George D
Publicado 2014