Structural biology in antiviral drug discovery

por Bassetto, Marcella, Massarotti, Alberto, Coluccia, Antonio, Brancale, Andrea
Publicado 2016

Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

por Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Publicado 2017

Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

por Bassetto, Marcella, Van Dycke, Jana, Neyts, Johan, Brancale, Andrea, Rocha-Pereira, Joana
Publicado 2019

Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents

por Bassetto, Marcella, Ferla, Salvatore, Giancotti, Gilda, Pertusati, Fabrizio, Westwell, Andrew D., Brancale, Andrea, McGuigan, Christopher
Publicado 2017

SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response

por Queirós-Reis, Luís, Gomes da Silva, Priscilla, Gonçalves, José, Brancale, Andrea, Bassetto, Marcella, Mesquita, João R.
Publicado 2021

CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251

por Hucke, Friederike I. L., Bestehorn-Willmann, Malena, Bassetto, Marcella, Brancale, Andrea, Zanetta, Paola, Bugert, Joachim J.
Publicado 2022

Novel Nucleoside Analogues as Effective Antiviral Agents for Zika Virus Infections

por Bassetto, Marcella, Cima, Cecilia M., Basso, Mattia, Salerno, Martina, Schwarze, Frank, Friese, Daniela, Bugert, Joachim J., Brancale, Andrea
Publicado 2020

A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase

por Giancotti, Gilda, Rigo, Ilaria, Pasqualetto, Gaia, Young, Mark T., Neyts, Johan, Rocha-Pereira, Joana, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Publicado 2019

Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

por Elajnaf, Taha, Iamartino, Luca, Mesteri, Ildiko, Müller, Christian, Bassetto, Marcella, Manhardt, Teresa, Baumgartner-Parzer, Sabina, Kallay, Enikö, Schepelmann, Martin
Publicado 2019

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

por Flude, Ben M., Nannetti, Giulio, Mitchell, Paige, Compton, Nina, Richards, Chloe, Heurich, Meike, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Publicado 2021

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

por Ferla, Salvatore, Netzler, Natalie E., Ferla, Sebastiano, Veronese, Sofia, Tuipulotu, Daniel Enosi, Guccione, Salvatore, Brancale, Andrea, White, Peter A., Bassetto, Marcella
Publicado 2018

Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

por Pasqualetto, Gaia, Schepelmann, Martin, Varricchio, Carmine, Pileggi, Elisa, Khogali, Caroline, Morgan, Siân R., Boostrom, Ian, Rozanowska, Malgorzata, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Publicado 2020

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

por Schepelmann, Martin, Kupper, Nadja, Sladczyk, Marta, Mansfield, Bethan, Manhardt, Teresa, Piatek, Karina, Iamartino, Luca, Riccardi, Daniela, Kariuki, Benson M., Bassetto, Marcella, Kallay, Enikö
Publicado 2021

A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis

por Gill, Martin R., Jarman, Paul J., Hearnden, Vanessa, Fairbanks, Simon D, Bassetto, Marcella, Maib, Hannes, Palmer, John, Ayscough, Kathryn R., Thomas, Jim A., Smythe, Carl
Publicado 2022

Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

por Thames, Joy E., Waters, Charles D., Valle, Coralie, Bassetto, Marcella, Aouadi, Wahiba, Martin, Baptiste, Selisko, Barbara, Falat, Arissa, Coutard, Bruno, Brancale, Andrea, Canard, Bruno, Decroly, Etienne, Seley-Radtke, Katherine L.
Publicado 2020

The calcium-sensing receptor modulates the prostaglandin E(2) pathway in intestinal inflammation

por Gushchina, Valeriya, Kupper, Nadja, Schwarzkopf, Michael, Frisch, Gitta, Piatek, Karina, Aigner, Cornelia, Michel, Alexandra, Schueffl, Hemma, Iamartino, Luca, Elajnaf, Taha, Manhardt, Teresa, Vlasaty, Andrea, Heffeter, Petra, Bassetto, Marcella, Kállay, Enikö, Schepelmann, Martin
Publicado 2023

Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

por Ferla, Salvatore, Varricchio, Carmine, Knight, William, Ho, Pui Kei, Saporito, Fabiana, Tropea, Beatrice, Fagan, Giulio, Flude, Ben Matthew, Bevilacqua, Federica, Santos-Ferreira, Nanci, Van Dycke, Jana, Neyts, Johan, Brancale, Andrea, Rocha-Pereira, Joana, Bassetto, Marcella
Publicado 2021

Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

por Giancotti, Gilda, Nannetti, Giulio, Padalino, Gilda, Landini, Martina, Santos-Ferreira, Nanci, Van Dycke, Jana, Naccarato, Valentina, Patel, Usheer, Silvestri, Romano, Neyts, Johan, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jésus, Rocha-Pereira, Joana, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Publicado 2022

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

por Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T., Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2021

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

por Bauer, Lisa, Manganaro, Roberto, Zonsics, Birgit, Hurdiss, Daniel L., Zwaagstra, Marleen, Donselaar, Tim, Welter, Naemi G. E., van Kleef, Regina G. D. M., Lopez, Moira Lorenzo, Bevilacqua, Federica, Raman, Thamidur, Ferla, Salvatore, Bassetto, Marcella, Neyts, Johan, Strating, Jeroen R. P. M., Westerink, Remco H. S., Brancale, Andrea, van Kuppeveld, Frank J. M.
Publicado 2020