Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes

por Morgens, David W, Deans, Richard M, Li, Amy, Bassik, Michael C
Publicado 2016

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

por Han, Kyuho, Jeng, Edwin E., Hess, Gaelen T., Morgens, David W., Li, Amy, Bassik, Michael C.
Publicado 2017

Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

por Lu, Albert, Wawro, Paulina, Morgens, David W, Portela, Fernando, Bassik, Michael C, Pfeffer, Suzanne R
Publicado 2018

Weak base pairing in both seed and 3′ regions reduces RNAi off-targets and enhances si/shRNA designs

por Gu, Shuo, Zhang, Yue, Jin, Lan, Huang, Yong, Zhang, Feijie, Bassik, Michael C., Kampmann, Martin, Kay, Mark A.
Publicado 2014

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

por Siepe, Dirk H, Henneberg, Lukas T, Wilson, Steven C, Hess, Gaelen T, Bassik, Michael C, Zinn, Kai, Garcia, K Christopher
Publicado 2022

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

por Cohen, Allison, Jeng, Edwin E., Voorhies, Mark, Symington, Jane, Ali, Nebat, Rodriguez, Rosa A., Bassik, Michael C., Sil, Anita
Publicado 2022

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

por Liu, Qi, Gupta, Amita, Okesli-Armlovich, Ayse, Qiao, Wenjie, Fischer, Curt R., Smith, Mark, Carette, Jan E., Bassik, Michael C., Khosla, Chaitan
Publicado 2020

Astrocyte‐to‐astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation

por Li, Jiwen, Khankan, Rana R., Caneda, Christine, Godoy, Marlesa I., Haney, Michael S., Krawczyk, Mitchell C., Bassik, Michael C., Sloan, Steven A., Zhang, Ye
Publicado 2019

Rapid Creation and Quantitative Monitoring of High Coverage shRNA Libraries

por Bassik, Michael C., Lebbink, Robert Jan, Churchman, L. Stirling, Ingolia, Nicholas T., Patena, Weronika, LeProust, Emily M., Schuldiner, Maya, Weissman, Jonathan S., McManus, Michael T.
Publicado 2009

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

por Scharenberg, Samantha G., Dong, Wentao, Ghoochani, Ali, Nyame, Kwamina, Levin-Konigsberg, Roni, Krishnan, Aswini R., Rawat, Eshaan S., Spees, Kaitlyn, Bassik, Michael C., Abu-Remaileh, Monther
Publicado 2023

Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD

por Latallo, Malgorzata J., Wang, Shaopeng, Dong, Daoyuan, Nelson, Blake, Livingston, Nathan M., Wu, Rong, Zhao, Ning, Stasevich, Timothy J., Bassik, Michael C., Sun, Shuying, Wu, Bin
Publicado 2023

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

por Coukos, Robert, Yao, David, Sanchez, Mateo I, Strand, Eric T, Olive, Meagan E, Udeshi, Namrata D, Weissman, Jonathan S, Carr, Steven A, Bassik, Michael C, Ting, Alice Y
Publicado 2021

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

por Kim, Garam, Nakayama, Lisa, Blum, Jacob A., Akiyama, Tetsuya, Boeynaems, Steven, Chakraborty, Meenakshi, Couthouis, Julien, Tassoni-Tsuchida, Eduardo, Rodriguez, Caitlin M., Bassik, Michael C., Gitler, Aaron D.
Publicado 2022

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

por Durrant, Matthew G., Fanton, Alison, Tycko, Josh, Hinks, Michaela, Chandrasekaran, Sita S., Perry, Nicholas T., Schaepe, Julia, Du, Peter P., Lotfy, Peter, Bassik, Michael C., Bintu, Lacramioara, Bhatt, Ami S., Hsu, Patrick D.
Publicado 2022

CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping

por Marinov, Georgi K., Kim, Samuel H., Bagdatli, S. Tansu, Higashino, Soon Il, Trevino, Alexandro E., Tycko, Josh, Wu, Tong, Bintu, Lacramioara, Bassik, Michael C., He, Chuan, Kundaje, Anshul, Greenleaf, William J.
Publicado 2023

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment

por Meng, Xiangling, Yao, David, Imaizumi, Kent, Chen, Xiaoyu, Kelley, Kevin W., Reis, Noah, Thete, Mayuri Vijay, Arjun McKinney, Arpana, Kulkarni, Shravanti, Panagiotakos, Georgia, Bassik, Michael C., Pașca, Sergiu P.
Publicado 2023

Unraveling the mechanism of cell death induced by chemical fibrils

por Julien, Olivier, Kampmann, Martin, Bassik, Michael C., Zorn, Julie A., Venditto, Vincent J., Shimbo, Kazutaka, Agard, Nicholas J., Shimada, Kenichi, Rheingold, Arnold L., Stockwell, Brent R., Weissman, Jonathan S., Wells, James A.
Publicado 2014

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

por Breslow, David K., Hoogendoorn, Sascha, Kopp, Adam R., Morgens, David W., Vu, Brandon K., Kennedy, Margaret C., Han, Kyuho, Li, Amy, Hess, Gaelen T., Bassik, Michael C., Chen, James K., Nachury, Maxence V.
Publicado 2018

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

por Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Publicado 2016

Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia

por Grüninger, Patricia K., Uhl, Franziska, Herzog, Heike, Gentile, Gaia, Andrade-Martinez, Marta, Schmidt, Tobias, Han, Kyuho, Morgens, David W., Bassik, Michael C., Cleary, Michael L., Gorka, Oliver, Zeiser, Robert, Groß, Olaf, Duque-Afonso, Jesús
Publicado 2022