Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

por Darzentas, Franziska, Szczepanowski, Monika, Kotrová, Michaela, Hartmann, Alina, Beder, Thomas, Gökbuget, Nicola, Schwartz, Stefan, Bastian, Lorenz, Baldus, Claudia Dorothea, Pál, Karol, Darzentas, Nikos, Brüggemann, Monika
Publicado 2023

IGH Rearrangement Evolution in Adult KMT2A-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

por Darzentas, Franziska, Szczepanowski, Monika, Kotrová, Michaela, Kelm, Miriam, Hartmann, Alina, Beder, Thomas, Gökbuget, Nicola, Neumann, Martin, Bastian, Lorenz, Baldus, Claudia D., Pál, Karol, Darzentas, Nikos, Brüggemann, Monika
Publicado 2022

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab

por Baumann, Niklas, Arndt, Christian, Petersen, Judith, Lustig, Marta, Rösner, Thies, Klausz, Katja, Kellner, Christian, Bultmann, Miriam, Bastian, Lorenz, Vogiatzi, Fotini, Leusen, Jeanette H. W., Burger, Renate, Schewe, Denis M., Peipp, Matthias, Valerius, Thomas
Publicado 2022

AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL

por Spory, Lea, Zimmermann, Johannes, Vossen-Gajcy, Michaela, Beder, Thomas, Bastian, Lorenz, Alsadeq, Ameera, Winterberg, Dorothee, Vogiatzi, Fotini, Wirbelauer, Tim, Bhat, Hilal, Borkhardt, Arndt, Bhatia, Sanil, Schrappe, Martin, Cario, Gunnar, Schewe, Denis M., Lenk, Lennart
Publicado 2023

Chemotherapy‐induced release of ADAM17 bearing EV as a potential resistance mechanism in ovarian cancer

por Hugendieck, Gerrit, Lettau, Marcus, Andreas, Svenja, Neumann, Sabrina, Reinhardt, Natalie, Arnold, Philipp, Theilig, Franziska, Bastian, Lorenz, Rogmans, Christoph, Weimer, Jörg P., Flörkemeier, Inken, Wesch, Daniela, Arnold, Norbert, Maass, Nicolai, Janssen, Ottmar, Bauerschlag, Dirk, Hedemann, Nina
Publicado 2023

Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells

por Lustig, Marta, Chan, Chilam, Jansen, J. H. Marco, Bräutigam, Maria, Kölling, Max A., Gehlert, Carina Lynn, Baumann, Niklas, Mester, Simone, Foss, Stian, Andersen, Jan Terje, Bastian, Lorenz, Sondermann, Peter, Peipp, Matthias, Burger, Renate, Leusen, Jeanette H. W., Valerius, Thomas
Publicado 2023

An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse

por Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Publicado 2022

FAT1 expression in T-cell acute lymphoblastic leukemia (T-ALL) modulates proliferation and WNT signaling

por Liebig, Sven, Neumann, Martin, Silva, Patricia, Ortiz-Tanchez, Jutta, Schulze, Veronika, Isaakidis, Konstandina, Schlee, Cornelia, Schroeder, Michael P., Beder, Thomas, Morris, Luc G. T., Chan, Timothy A., Bastian, Lorenz, Burmeister, Thomas, Schwartz, Stefan, Gökbuget, Nicola, Mochmann, Liliana H., Baldus, Claudia D.
Publicado 2023

Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)

por Steinhäuser, Sophie, Silva, Patricia, Lenk, Lennart, Beder, Thomas, Hartmann, Alina, Hänzelmann, Sonja, Fransecky, Lars, Neumann, Martin, Bastian, Lorenz, Lipinski, Simone, Richter, Kathrin, Bultmann, Miriam, Hübner, Emely, Xia, Shuli, Röllig, Christoph, Vogiatzi, Fotini, Schewe, Denis Martin, Yumiceba, Veronica, Schultz, Kristin, Spielmann, Malte, Baldus, Claudia Dorothea
Publicado 2022

Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia

por Chitadze, Guranda, Stengel, Anna, John-Klaua, Cathrin, Bruckmüller, Julien, Trautmann, Heiko, Kotrova, Michaela, Darzentas, Franziska, Kelm, Miriam, Pal, Karol, Darzentas, Nikos, Bastian, Lorenz, Kehden, Britta, Wessels, Wiebke, Ströh, Aeint-Steffen, Oberg, Hans-Heinrich, Altrock, Philipp M., Baer, Constance, Meggendorfer, Manja, Gökbuget, Nicola, Baldus, Claudia D., Haferlach, Claudia, Brüggemann, Monika
Publicado 2023

Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation

por Lázaro-Navarro, Juan, Pimentel-Gutiérrez, Helia Judith, Gauert, Anton, Hagemann, Anja I. H., Eisenschmid, Jassi, Gökbuget, Nicola, Vick, Binje, Jeremias, Irmela, Seyfried, Felix, Meyer, Lüder Hinrich, Debatin, Klaus-Michael, Richer, Kathrin, Bultman, Miriam, Neumann, Martin, Hänzelmann, Sonja, Serve, Hubert, Astrahantseff, Kathy, Rieger, Michael A., Eckert, Cornelia, Baldus, Claudia D., Bastian, Lorenz
Publicado 2021

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

por James, Alva Rani, Schroeder, Michael P., Neumann, Martin, Bastian, Lorenz, Eckert, Cornelia, Gökbuget, Nicola, Tanchez, Jutta Ortiz, Schlee, Cornelia, Isaakidis, Konstandina, Schwartz, Stefan, Burmeister, Thomas, von Stackelberg, Arend, Rieger, Michael A., Göllner, Stefanie, Horstman, Martin, Schrappe, Martin, Kirschner-Schwabe, Renate, Brüggemann, Monika, Müller-Tidow, Carsten, Serve, Hubert, Akalin, Altuna, Baldus, Claudia D.
Publicado 2019

The Gene Expression Classifier ALLCatchR Identifies B-cell Precursor ALL Subtypes and Underlying Developmental Trajectories Across Age

por Beder, Thomas, Hansen, Björn-Thore, Hartmann, Alina M., Zimmermann, Johannes, Amelunxen, Eric, Wolgast, Nadine, Walter, Wencke, Zaliova, Marketa, Antić, Željko, Chouvarine, Philippe, Bartsch, Lorenz, Barz, Malwine J., Bultmann, Miriam, Horns, Johanna, Bendig, Sonja, Kässens, Jan, Kaleta, Christoph, Cario, Gunnar, Schrappe, Martin, Neumann, Martin, Gökbuget, Nicola, Bergmann, Anke Katharina, Trka, Jan, Haferlach, Claudia, Brüggemann, Monika, Baldus, Claudia D., Bastian, Lorenz
Publicado 2023

UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment

por Bastian, Lorenz, Hartmann, Alina M., Beder, Thomas, Hänzelmann, Sonja, Kässens, Jan, Bultmann, Miriam, Hoeppner, Marc P., Franzenburg, Sören, Wittig, Michael, Franke, Andre, Nagel, Inga, Spielmann, Malte, Reimer, Niklas, Busch, Hauke, Schwartz, Stefan, Steffen, Björn, Viardot, Andreas, Döhner, Konstanze, Kondakci, Mustafa, Wulf, Gerald, Wendelin, Knut, Renzelmann, Andrea, Kiani, Alexander, Trautmann, Heiko, Neumann, Martin, Gökbuget, Nicola, Brüggemann, Monika, Baldus, Claudia D.
Publicado 2022

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

por Carlet, Michela, Völse, Kerstin, Vergalli, Jenny, Becker, Martin, Herold, Tobias, Arner, Anja, Senft, Daniela, Jurinovic, Vindi, Liu, Wen-Hsin, Gao, Yuqiao, Dill, Veronika, Fehse, Boris, Baldus, Claudia D., Bastian, Lorenz, Lenk, Lennart, Schewe, Denis M., Bagnoli, Johannes W., Vick, Binje, Schmid, Jan Philipp, Wilhelm, Alexander, Marschalek, Rolf, Jost, Philipp J., Miething, Cornelius, Riecken, Kristoffer, Schmidt-Supprian, Marc, Binder, Vera, Jeremias, Irmela
Publicado 2021

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

por Das Gupta, Dennis, Paul, Christoph, Samel, Nadine, Bieringer, Maria, Staudenraus, Daniel, Marini, Federico, Raifer, Hartmann, Menke, Lisa, Hansal, Lea, Camara, Bärbel, Roth, Edith, Daum, Patrick, Wanzel, Michael, Mernberger, Marco, Nist, Andrea, Bauer, Uta-Maria, Helmprobst, Frederik, Buchholz, Malte, Roth, Katrin, Bastian, Lorenz, Hartmann, Alina M., Baldus, Claudia, Ikuta, Koichi, Neubauer, Andreas, Burchert, Andreas, Jäck, Hans-Martin, Klein, Matthias, Bopp, Tobias, Stiewe, Thorsten, Pagenstecher, Axel, Lohoff, Michael
Publicado 2022

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

por Schroeder, Michael P., Bastian, Lorenz, Eckert, Cornelia, Gökbuget, Nicola, James, Alva Rani, Tanchez, Jutta Ortiz, Schlee, Cornelia, Isaakidis, Konstandina, Häupl, Björn, Baum, Katharina, Migueles Lozano, Oscar Arturo, Kouidri, Khouloud, Pan, Kuan-Ting, Urlaub, Henning, Schwartz, Stefan, Burmeister, Thomas, von Stackelberg, Arend, Hoelzer, Dieter, Pfeiffer, Heike, Rieger, Michael A., Göllner, Stefanie, Oellerich, Thomas, Horstman, Martin, Schrappe, Martin, Wolf, Jana, Kirschner-Schwabe, Renate, Brüggemann, Monika, Müller-Tidow, Carsten, Serve, Hubert, Neumann, Martin, Baldus, Claudia D.
Publicado 2019