Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap

por Bate, Neil, Lodge, James, Brindle, Nicholas P.J.
Publicado 2021

Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain

por Chandru, Aditya, Bate, Neil, Vuister, Geerten W., Cowley, Shaun M.
Publicado 2018

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

por Margadant, Felix, Chew, Li Li, Hu, Xian, Yu, Hanry, Bate, Neil, Zhang, Xian, Sheetz, Michael
Publicado 2011

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site

por Goult, Benjamin T., Gingras, Alexandre R., Bate, Neil, Barsukov, Igor L., Critchley, David R., Roberts, Gordon C.K.
Publicado 2010

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

por Bate, Neil, Gingras, Alexandre R., Bachir, Alexia, Horwitz, Rick, Ye, Feng, Patel, Bipin, Goult, Benjamin T., Critchley, David R.
Publicado 2012

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

por Debrand, Emmanuel, El Jai, Yasmine, Spence, Lorraine, Bate, Neil, Praekelt, Uta, Pritchard, Catrin A, Monkley, Susan J, Critchley, David R
Publicado 2009

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

por Debrand, Emmanuel, Conti, Francesco J., Bate, Neil, Spence, Lorraine, Mazzeo, Daniela, Pritchard, Catrin A., Monkley, Susan J., Critchley, David R.
Publicado 2012

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

por Elliott, Paul R., Goult, Benjamin T., Kopp, Petra M., Bate, Neil, Grossmann, J. Günter, Roberts, Gordon C.K., Critchley, David R., Barsukov, Igor L.
Publicado 2010

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

por Gingras, Alexandre R., Bate, Neil, Goult, Benjamin T., Patel, Bipin, Kopp, Petra M., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Critchley, David R.
Publicado 2010

The Structure of an Interdomain Complex That Regulates Talin Activity

por Goult, Benjamin T., Bate, Neil, Anthis, Nicholas J., Wegener, Kate L., Gingras, Alexandre R., Patel, Bipin, Barsukov, Igor L., Campbell, Iain D., Roberts, Gordon C. K., Critchley, David R.
Publicado 2009

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

por Goult, Benjamin T., Bouaouina, Mohamed, Harburger, David S., Bate, Neil, Patel, Bipin, Anthis, Nicholas J., Campbell, Iain D., Calderwood, David A., Barsukov, Igor L., Roberts, Gordon C., Critchley, David R.
Publicado 2009

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

por Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C. K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.
Publicado 2013

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

por Bate, Neil, Savva, Christos G., Moody, Peter C. E., Brown, Edward A., Evans, Sian E., Ball, Jonathan K., Schwabe, John W. R., Sale, Julian E., Brindle, Nicholas P. J.
Publicado 2022

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

por Goult, Benjamin T, Bouaouina, Mohamed, Elliott, Paul R, Bate, Neil, Patel, Bipin, Gingras, Alexandre R, Grossmann, J Günter, Roberts, Gordon C K, Calderwood, David A, Critchley, David R, Barsukov, Igor L
Publicado 2010

Vinculin controls talin engagement with the actomyosin machinery

por Atherton, Paul, Stutchbury, Ben, Wang, De-Yao, Jethwa, Devina, Tsang, Ricky, Meiler-Rodriguez, Eugenia, Wang, Pengbo, Bate, Neil, Zent, Roy, Barsukov, Igor L., Goult, Benjamin T., Critchley, David R., Ballestrem, Christoph
Publicado 2015

The structure of the C-terminal actin-binding domain of talin

por Gingras, Alexandre R, Bate, Neil, Goult, Benjamin T, Hazelwood, Larnele, Canestrelli, Ilona, Grossmann, J Günter, Liu, HongJun, Putz, Nicholas S M, Roberts, Gordon C K, Volkmann, Niels, Hanein, Dorit, Barsukov, Igor L, Critchley, David R
Publicado 2008

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

por Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.
Publicado 2010

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2

por Praekelt, Uta, Kopp, Petra M., Rehm, Kerstin, Linder, Stefan, Bate, Neil, Patel, Bipin, Debrand, Emmanuel, Manso, Ana Maria, Ross, Robert S., Conti, Franceso, Zhang, Ming-Zhi, Harris, Raymond C., Zent, Roy, Critchley, David R., Monkley, Susan J.
Publicado 2012

Structural Determinants of Integrin Binding to the Talin Rod

por Gingras, Alexandre R., Ziegler, Wolfgang H., Bobkov, Andrey A., Joyce, M. Gordon, Fasci, Domenico, Himmel, Mirko, Rothemund, Sven, Ritter, Anett, Grossmann, J. Günter, Patel, Bipin, Bate, Neil, Goult, Benjamin T., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Liddington, Robert C., Ginsberg, Mark H., Critchley, David R.
Publicado 2009