Challenges and progress in research, diagnostics, and therapeutics in Alzheimer's disease and related dementias

por Dokholyan, Nikolay V., Mohs, Richard C., Bateman, Randall J.
Publicado 2022

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

por Barthélemy, Nicolas R., Horie, Kanta, Sato, Chihiro, Bateman, Randall J.
Publicado 2020

Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios

por Janelidze, Shorena, Barthélemy, Nicolas R., He, Yingxin, Bateman, Randall J., Hansson, Oskar
Publicado 2023

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzh...

por Barthélemy, Nicolas R., Mallipeddi, Nipun, Moiseyev, Paul, Sato, Chihiro, Bateman, Randall J.
Publicado 2019

Diurnal oscillation of CSF Aβ and other AD biomarkers

por Lucey, Brendan P., Fagan, Anne M., Holtzman, David M., Morris, John C., Bateman, Randall J.
Publicado 2017

Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

por Elbert, Donald L., Patterson, Bruce W., Lucey, Brendan P., Benzinger, Tammie L. S., Bateman, Randall J.
Publicado 2022

The informed road map to prevention of Alzheimer Disease: A call to arms

por McDade, Eric, Llibre-Guerra, Jorge J., Holtzman, David M., Morris, John C., Bateman, Randall J.
Publicado 2021

Plasma amyloid-β42/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer’s disease

por Cullen, Nicholas C, Janelidze, Shorena, Stomrud, Erik, Bateman, Randall J, Palmqvist, Sebastian, Hansson, Oskar, Mattsson-Carlgren, Niklas
Publicado 2023

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

por Barthélemy, Nicolas R., Bateman, Randall J., Hirtz, Christophe, Marin, Philippe, Becher, François, Sato, Chihiro, Gabelle, Audrey, Lehmann, Sylvain
Publicado 2020

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains

por Esparza, Thomas J., Wildburger, Norelle C., Jiang, Hao, Gangolli, Mihika, Cairns, Nigel J., Bateman, Randall J., Brody, David L.
Publicado 2016

The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method

por Dobrowolska Zakaria, Justyna A., Bateman, Randall J., Lysakowska, Monika, Khatri, Ammaarah, Jean-Gilles, Dinorah, Kennedy, Matthew E., Vassar, Robert
Publicado 2022

Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System

por Dobrowolska, Justyna A., Kasten, Tom, Huang, Yafei, Benzinger, Tammie L. S., Sigurdson, Wendy, Ovod, Vitaliy, Morris, John C., Bateman, Randall J.
Publicado 2014

Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain

por Horie, Kanta, Barthélemy, Nicolas R., Mallipeddi, Nipun, Li, Yan, Franklin, Erin E., Perrin, Richard J., Bateman, Randall J., Sato, Chihiro
Publicado 2020

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

por Moulder, Krista L, Snider, B Joy, Mills, Susan L, Buckles, Virginia D, Santacruz, Anna M, Bateman, Randall J, Morris, John C
Publicado 2013

Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults

por He, Lingxiao, de Souto Barreto, Philipe, Aggarwal, Geetika, Nguyen, Andrew D., Morley, John E., Li, Yan, Bateman, Randall J., Vellas, Bruno
Publicado 2020

A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer’s disease

por Grill, Joshua D., Bateman, Randall J., Buckles, Virginia, Oliver, Angela, Morris, John C., Masters, Colin L., Klunk, William E., Ringman, John M.
Publicado 2015

Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype

por Li, Huifangjie, Knight, William C., Yang, Pengfei, Guo, Yingqiu, Perlmutter, Joel S., Morris, John C., Bateman, Randall J., Benzinger, Tammie L. S., Xu, Jinbin
Publicado 2020

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

por Basak, Jacob M, Kim, Jungsu, Pyatkivskyy, Yuriy, Wildsmith, Kristin R, Jiang, Hong, Parsadanian, Maia, Patterson, Bruce W, Bateman, Randall J, Holtzman, David M
Publicado 2012

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

por Ghosal, Kaushik, Haag, Michael, Verghese, Philip B., West, Tim, Veenstra, Tim, Braunstein, Joel B., Bateman, Randall J., Holtzman, David M., Landreth, Gary E.
Publicado 2016

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated

por Barthélemy, Nicolas R., Toth, Balazs, Manser, Paul T., Sanabria-Bohórquez, Sandra, Teng, Edmond, Keeley, Michael, Bateman, Randall J., Weimer, Robby M., Wildsmith, Kristin R.
Publicado 2022