Current strategies for the design of PROTAC linkers: a critical review

por Troup, Robert I., Fallan, Charlene, Baud, Matthias G. J.
Publicado 2020

New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition

por Baud, Matthias G. J., Lin-Shiao, Enrique, Zengerle, Michael, Tallant, Cynthia, Ciulli, Alessio
Publicado 2015

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale

por McCoy, Michael A., Spicer, Dominique, Wells, Neil, Hoogewijs, Kurt, Fiedler, Marc, Baud, Matthias G. J.
Publicado 2022

Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

por Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D., Baud, Matthias G. J., Ciulli, Alessio, Spencer, John
Publicado 2017

Dual wavelength asymmetric photochemical synthesis with circularly polarized light

por Richardson, Robert D., Baud, Matthias G. J., Weston, Claire E., Rzepa, Henry S., Kuimova, Marina K., Fuchter, Matthew J.
Publicado 2015

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

por Baud, Matthias G J, Leiser, Thomas, Petrucci, Vanessa, Gunaratnam, Mekala, Neidle, Stephen, Meyer-Almes, Franz-Josef, Fuchter, Matthew J
Publicado 2013

Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?

por Dias, David M., Van Molle, Inge, Baud, Matthias G. J., Galdeano, Carles, Geraldes, Carlos F. G. C., Ciulli, Alessio
Publicado 2013

Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy

por Chasov, Vitaly, Mirgayazova, Regina, Zmievskaya, Ekaterina, Khadiullina, Raniya, Valiullina, Aygul, Stephenson Clarke, Joseph, Rizvanov, Albert, Baud, Matthias G. J., Bulatov, Emil
Publicado 2020

Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

por Bauer, Matthias R., Jones, Rhiannon N., Baud, Matthias G. J., Wilcken, Rainer, Boeckler, Frank M., Fersht, Alan R., Joerger, Andreas C., Spencer, John
Publicado 2016

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

por Baud, Matthias G.J., Bauer, Matthias R., Verduci, Lorena, Dingler, Felix A., Patel, Ketan J., Horil Roy, Deeptee, Joerger, Andreas C., Fersht, Alan R.
Publicado 2018

Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C

por Stephenson Clarke, Joseph R., Douglas, Leon R., Duriez, Patrick J., Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Khadiullina, Raniya, Bulatov, Emil, Baud, Matthias G. J.
Publicado 2022

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

por Joerger, Andreas C., Bauer, Matthias R., Wilcken, Rainer, Baud, Matthias G.J., Harbrecht, Hannes, Exner, Thomas E., Boeckler, Frank M., Spencer, John, Fersht, Alan R.
Publicado 2015

Structure–Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation

por Pichon, Maëva M., Drelinkiewicz, Dawid, Lozano, David, Moraru, Ruxandra, Hayward, Laura J., Jones, Megan, McCoy, Michael A., Allstrum-Graves, Samuel, Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Whitby, Richard J., Goldup, Stephen M., Wells, Neil, Langley, Graham J., Herniman, Julie M., Baud, Matthias G. J.
Publicado 2023