Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

por Kranz, Philip, Sänger, Christopher, Wolf, Alexandra, Baumann, Jennifer, Metzen, Eric, Baumann, Melanie, Göpelt, Kirsten, Brockmeier, Ulf
Publicado 2020

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis

por Küper, Alina, Baumann, Jennifer, Göpelt, Kirsten, Baumann, Melanie, Sänger, Christopher, Metzen, Eric, Kranz, Philip, Brockmeier, Ulf
Publicado 2021

In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway

por Ocklenburg, Tobias, Neumann, Fabian, Wolf, Alexandra, Vogel, Julia, Göpelt, Kirsten, Baumann, Melanie, Baumann, Jennifer, Kranz, Philip, Metzen, Eric, Brockmeier, Ulf
Publicado 2021

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

por Kranz, Philip, Neumann, Fabian, Wolf, Alexandra, Classen, Fabian, Pompsch, Mosche, Ocklenburg, Tobias, Baumann, Jennifer, Janke, Kirsten, Baumann, Melanie, Goepelt, Kirsten, Riffkin, Helena, Metzen, Eric, Brockmeier, Ulf
Publicado 2017