Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial

por Micallef, Sandrine, Sostelly, Alexandre, Zhu, Jiawen, Baverel, Paul G., Mercier, Francois
Publicado 2022

Model enhanced reinforcement learning to enable precision dosing: A theoretical case study with dosing of propofol

por Ribba, Benjamin, Bräm, Dominic Stefan, Baverel, Paul Gabriel, Peck, Richard Wilson
Publicado 2022

Early predictions of response and survival from a tumor dynamics model in patients with recurrent, metastatic head and neck squamous cell carcinoma treated with immunotherapy

por González‐García, Ignacio, Pierre, Vadryn, Dubois, Vincent F. S., Morsli, Nassim, Spencer, Stuart, Baverel, Paul G., Moore, Helen
Publicado 2021

Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total

por Hood, John, González-García, Ignacio, White, Nicholas, Marshall, Leeron, Dubois, Vincent F. S., Vicini, Paolo, Baverel, Paul G.
Publicado 2021

Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

por Truong, Van Thuy, Baverel, Paul G., Lythe, Grant D., Vicini, Paolo, Yates, James W. T., Dubois, Vincent F. S.
Publicado 2022

Exposure–Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status

por Baverel, Paul, Roskos, Lorin, Tatipalli, Manasa, Lee, Nancy, Stockman, Paul, Taboada, Maria, Vicini, Paolo, Horgan, Kevin, Narwal, Rajesh
Publicado 2019

Association of circulating protein biomarkers with clinical outcomes of durvalumab in head and neck squamous cell carcinoma

por Arends, Rosalinda, Guo, Xiang, Baverel, Paul G., González-García, Ignacio, Xie, James, Morsli, Nassim, Yovine, Alejandro, Roskos, Lorin K.
Publicado 2021

Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients With Urothelial Carcinoma

por Zheng, Yanan, Narwal, Rajesh, Jin, ChaoYu, Baverel, Paul G., Jin, Xiaoping, Gupta, Ashok, Ben, Yong, Wang, Bing, Mukhopadhyay, Pralay, Higgs, Brandon W., Roskos, Lorin
Publicado 2018

Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status

por Baverel, Paul G., Dubois, Vincent F.S., Jin, Chao Yu, Zheng, Yanan, Song, Xuyang, Jin, Xiaoping, Mukhopadhyay, Pralay, Gupta, Ashok, Dennis, Phillip A., Ben, Yong, Vicini, Paolo, Roskos, Lorin, Narwal, Rajesh
Publicado 2018

A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development

por Ruiz-Garcia, Ana, Baverel, Paul, Bottino, Dean, Dolton, Michael, Feng, Yan, González-García, Ignacio, Kim, Jaeyeon, Robey, Seth, Singh, Indrajeet, Turner, David, Wu, Shu-Pei, Yin, Donghua, Zhou, Di, Zhu, Hao, Bonate, Peter
Publicado 2023