DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion

por Bax, Benjamin D., Murshudov, Garib, Maxwell, Anthony, Germe, Thomas
Publicado 2019

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase

por Fenn, Gareth D., Waller-Evans, Helen, Atack, John R., Bax, Benjamin D.
Publicado 2020

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

por Germe, Thomas, Vörös, Judit, Jeannot, Frederic, Taillier, Thomas, Stavenger, Robert A, Bacqué, Eric, Maxwell, Anthony, Bax, Benjamin D
Publicado 2018

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

por Germe, Thomas, Vörös, Judit, Jeannot, Frederic, Taillier, Thomas, Stavenger, Robert A, Bacqué, Eric, Maxwell, Anthony, Bax, Benjamin D
Publicado 2018

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

por Koulouris, Chloe R., Gardiner, Sian E., Harris, Tessa K., Elvers, Karen T., Mark Roe, S., Gillespie, Jason A., Ward, Simon E., Grubisha, Olivera, Nicholls, Robert A., Atack, John R., Bax, Benjamin D.
Publicado 2022

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

por Slade, Daniel J., Fang, Pengfei, Dreyton, Christina J., Zhang, Ying, Fuhrmann, Jakob, Rempel, Don, Bax, Benjamin D., Coonrod, Scott A., Lewis, Huw D., Guo, Min, Gross, Michael L., Thompson, Paul R.
Publicado 2015

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

por Li, Dianfan, Howe, Nicole, Dukkipati, Abhiram, Shah, Syed T. A., Bax, Benjamin D., Edge, Colin, Bridges, Angela, Hardwicke, Phil, Singh, Onkar M. P., Giblin, Ged, Pautsch, Alexander, Pfau, Roland, Schnapp, Gisela, Wang, Meitian, Olieric, Vincent, Caffrey, Martin
Publicado 2014

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

por Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.
Publicado 2015

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

por Lewis, Huw D., Liddle, John, Coote, Jim E., Atkinson, Stephen J., Barker, Michael D., Bax, Benjamin, D., Bicker, Kevin L., Bingham, Ryan P., Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D., Davis, Rob P., Eberhard, Dirk, Joberty, Gerard, Lind, Kenneth E., Locke, Kelly, Maller, Claire, Martinod, Kimberly, Patten, Chris, Polyakova, Oxana, Rise, Cecil E., Rüdiger, Martin, Sheppard, Robert J., Slade, Daniel J., Thomas, Pamela, Thorpe, Jim, Yao, Gang, Drewes, Gerard, Wagner, Denisa D., Thompson, Paul R., Prinjha, Rab K., Wilson, David M.
Publicado 2015