N-Truncated Aβ Starting at Position Four—Biochemical Features, Preclinical Models, and Potential as Drug Target in Alzheimer’s Disease

por Bayer, Thomas A.
Publicado 2021

Pyroglutamate Aβ cascade as drug target in Alzheimer’s disease

por Bayer, Thomas A.
Publicado 2021

Intracellular Accumulation of Amyloid-Beta – A Predictor for Synaptic Dysfunction and Neuron Loss in Alzheimer's Disease

por Bayer, Thomas A., Wirths, Oliver
Publicado 2010

Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

por Wirths, Oliver, Bayer, Thomas A.
Publicado 2010

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease

por Bayer, Thomas A., Wirths, Oliver
Publicado 2014

Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42

por Dietrich, Katharina, Bouter, Yvonne, Müller, Michael, Bayer, Thomas A.
Publicado 2018

SUMO1‐conjugation is altered during normal aging but not by increased amyloid burden

por Stankova, Trayana, Piepkorn, Lars, Bayer, Thomas A., Jahn, Olaf, Tirard, Marilyn
Publicado 2018

Disturbed Copper Bioavailability in Alzheimer's Disease

por Kaden, Daniela, Bush, Ashley I., Danzeisen, Ruth, Bayer, Thomas A., Multhaup, Gerd
Publicado 2011

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

por Wirths, Oliver, Breyhan, Henning, Cynis, Holger, Schilling, Stephan, Demuth, Hans-Ulrich, Bayer, Thomas A.
Publicado 2009

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

por Christensen, Ditte Z., Schneider-Axmann, Thomas, Lucassen, Paul J., Bayer, Thomas A., Wirths, Oliver
Publicado 2010

Reduced Acoustic Startle Response and Prepulse Inhibition in the Tg4-42 Model of Alzheimer’s Disease

por Sichler, Marius E., Löw, Maximilian J., Schleicher, Eva M., Bayer, Thomas A., Bouter, Yvonne
Publicado 2019

Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease

por Marcello, Andrea, Wirths, Oliver, Schneider-Axmann, Thomas, Degerman-Gunnarsson, Malin, Lannfelt, Lars, Bayer, Thomas A.
Publicado 2009

miRNA Alterations Elicit Pathways Involved in Memory Decline and Synaptic Function in the Hippocampus of Aged Tg4-42 Mice

por Bouter, Yvonne, Kacprowski, Tim, Rößler, Fanny, Jensen, Lars R., Kuss, Andreas W., Bayer, Thomas A.
Publicado 2020

In vivo Imaging With (18)F-FDG- and (18)F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

por Franke, Timon N., Irwin, Caroline, Bayer, Thomas A., Brenner, Winfried, Beindorff, Nicola, Bouter, Caroline, Bouter, Yvonne
Publicado 2020

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease

por Hinteregger, Barbara, Loeffler, Tina, Flunkert, Stefanie, Neddens, Joerg, Bayer, Thomas A., Madl, Tobias, Hutter-Paier, Birgit
Publicado 2021

Donanemab detects a minor fraction of amyloid-β plaques in post-mortem brain tissue of patients with Alzheimer’s disease and Down syndrome

por Bouter, Yvonne, Liekefeld, Hendrik, Pichlo, Steffen, Westhoff, Anna Celine, Fenn, Lydia, Bakrania, Preeti, Bayer, Thomas A.
Publicado 2022

Transgene integration causes RARB downregulation in homozygous Tg4–42 mice

por Hinteregger, Barbara, Loeffler, Tina, Flunkert, Stefanie, Neddens, Joerg, Birner-Gruenberger, Ruth, Bayer, Thomas A., Madl, Tobias, Hutter-Paier, Birgit
Publicado 2020

Ablation of the Presynaptic Protein Mover Impairs Learning Performance and Decreases Anxiety Behavior in Mice

por Schleicher, Eva Maria, Bayer, Thomas A., Iseni, Trendelina, Ott, Frederik Wilhelm, Wagner, Jannek Moritz, Viotti, Julio S., Dresbach, Thomas, Bouter, Yvonne
Publicado 2022

Search Strategy Analysis of 5xFAD Alzheimer Mice in the Morris Water Maze Reveals Sex- and Age-Specific Spatial Navigation Deficits

por Sánchez, Carolina Quintanilla, Schmitt, Franziska W., Curdt, Nadine, Westhoff, Anna Celine, Bänfer, Irina Wanda Helene, Bayer, Thomas A., Bouter, Yvonne
Publicado 2023

Abundance of Aβ(5-x) like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

por Guzmán, Erika Avendaño, Bouter, Yvonne, Richard, Bernhard C, Lannfelt, Lars, Ingelsson, Martin, Paetau, Anders, Verkkoniemi-Ahola, Auli, Wirths, Oliver, Bayer, Thomas A
Publicado 2014