An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

por Willis, Nicky J, Bayle, Elliott D, Papageorgiou, George, Steadman, David, Atkinson, Benjamin N, Mahy, William, Fish, Paul V
Publicado 2019

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling

por Bayle, Elliott D., Svensson, Fredrik, Atkinson, Benjamin N., Steadman, David, Willis, Nicky J., Woodward, Hannah L., Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V.
Publicado 2021

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

por Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Publicado 2020

Structural Analysis and Development of Notum Fragment Screening Hits

por Zhao, Yuguang, Mahy, William, Willis, Nicky J., Woodward, Hannah L., Steadman, David, Bayle, Elliott D., Atkinson, Benjamin N., Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C., Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V., Jones, E. Yvonne
Publicado 2022

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

por Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.
Publicado 2022

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

por Meier, Julia C., Tallant, Cynthia, Fedorov, Oleg, Witwicka, Hanna, Hwang, Sung-Yong, van Stiphout, Ruud G., Lambert, Jean-Philippe, Rogers, Catherine, Yapp, Clarence, Gerstenberger, Brian S., Fedele, Vita, Savitsky, Pavel, Heidenreich, David, Daniels, Danette L., Owen, Dafydd R., Fish, Paul V., Igoe, Niall M., Bayle, Elliott D., Haendler, Bernard, Oppermann, Udo C.T., Buffa, Francesca, Brennan, Paul E., Müller, Susanne, Gingras, Anne Claude, Odgren, Paul R., Birnbaum, Mark J., Knapp, Stefan
Publicado 2017