Editorial: In vitro toxicogenomics (TGx) in hazard and risk assessment

por Beal, Marc A., Everett, Logan J.
Publicado 2023

Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing

por Beal, Marc A., Gagné, Rémi, Williams, Andrew, Marchetti, Francesco, Yauk, Carole L.
Publicado 2015

Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia

por O’Brien, Jason M., Beal, Marc A., Yauk, Carole L., Marchetti, Francesco
Publicado 2016

Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identifies a germ cell-specific mutation spectrum

por O’Brien, Jason M., Beal, Marc A., Yauk, Carole L., Marchetti, Francesco
Publicado 2016

Implementing In Vitro Bioactivity Data to Modernize Priority Setting of Chemical Inventories

por Beal, Marc A., Gagne, Matthew, Kulkarni, Sunil A., Patlewicz, Grace, Thomas, Russell S.
Publicado 2022

Whole Genome Sequencing of the Mutamouse Model Reveals Strain- and Colony-Level Variation, and Genomic Features of the Transgene Integration Site

por Meier, Matthew J., Beal, Marc A., Schoenrock, Andrew, Yauk, Carole L., Marchetti, Francesco
Publicado 2019

Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals

por Bhuller, Yadvinder, Ramsingh, Deborah, Beal, Marc, Kulkarni, Sunil, Gagne, Matthew, Barton-Maclaren, Tara S
Publicado 2021

The functional mutational landscape of the lacZ gene

por Beal, Marc A., Meier, Matthew J., Dykes, Angela, Yauk, Carole L., Lambert, Iain B., Marchetti, Francesco
Publicado 2023

In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

por Meier, Matthew J., O’Brien, Jason M., Beal, Marc A., Allan, Beverly, Yauk, Carole L., Marchetti, Francesco
Publicado 2016

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

por O'Brien, Jason M., Beal, Marc A., Gingerich, John D., Soper, Lynda, Douglas, George R., Yauk, Carole L., Marchetti, Francesco
Publicado 2014

Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures

por Beal, Marc A., Meier, Matthew J., LeBlanc, Danielle P., Maurice, Clotilde, O’Brien, Jason M., Yauk, Carole L., Marchetti, Francesco
Publicado 2020

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutageni...

por Chepelev, Nikolai, Long, Alexandra S., Beal, Marc, Barton‐Maclaren, Tara, Johnson, George, Dearfield, Kerry L., Roberts, Daniel J., van Benthem, Jan, White, Paul
Publicado 2023

Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application

por Kuo, Byron, Beal, Marc A., Wills, John W., White, Paul A., Marchetti, Francesco, Nong, Andy, Barton-Maclaren, Tara S., Houck, Keith, Yauk, Carole L.
Publicado 2022

Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring

por Beal, Marc A., Meier, Matthew J., Williams, Andrew, Rowan-Carroll, Andrea, Gagné, Rémi, Lindsay, Sarah J., Fitzgerald, Tomas, Hurles, Matthew E., Marchetti, Francesco, Yauk, Carole L.
Publicado 2019

In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals

por Matteo, Geronimo, Leingartner, Karen, Rowan-Carroll, Andrea, Meier, Matthew, Williams, Andrew, Beal, Marc A, Gagné, Matthew, Farmahin, Reza, Wickramasuriya, Shamika, Reardon, Anthony J F, Barton-Maclaren, Tara, Christopher Corton, J, Yauk, Carole L, Atlas, Ella
Publicado 2022