Structure and Mechanism of DNA Polymerase β

por Beard, William A., Wilson, Samuel H.
Publicado 2014

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

por Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Publicado 2013

Watching a DNA polymerase in action

por Freudenthal, Bret D, Beard, William A, Wilson, Samuel H
Publicado 2014

DNA Polymerase β Gap-Filling Translesion DNA Synthesis

por Chary, Parvathi, Beard, William A., Wilson, Samuel H., Lloyd, R. Stephen
Publicado 2012

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts

por Chary, Parvathi, Beard, William A., Wilson, Samuel H., Lloyd, R. Stephen
Publicado 2013

Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer

por AN, CHANGLONG, BEARD, WILLIAM A., CHEN, DESHENG, WILSON, SAMUEL H., MAKRIDAKIS, NICK M.
Publicado 2013

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

por Shock, David D., Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Publicado 2017

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening

por Kim, Taejin, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar
Publicado 2016

Capturing Snapshots of APE1 Processing DNA Damage

por Freudenthal, Bret D., Beard, William A., Cuneo, Matthew J., Dyrkheeva, Nadezhda S., Wilson, Samuel H.
Publicado 2015

Revealing the role of the product metal in DNA polymerase β catalysis

por Perera, Lalith, Freudenthal, Bret D., Beard, William A., Pedersen, Lee G., Wilson, Samuel H.
Publicado 2017

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

por Perera, Lalith, Beard, William A., Pedersen, Lee G., Shock, David D., Wilson, Samuel H.
Publicado 2020

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

por Jamsen, Joonas A., Sassa, Akira, Shock, David D., Beard, William A., Wilson, Samuel H.
Publicado 2021

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

por Jamsen, Joonas A., Sassa, Akira, Perera, Lalith, Shock, David D., Beard, William A., Wilson, Samuel H.
Publicado 2021

Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

por Batra, Vinod K., Beard, William A., Hou, Esther W., Pedersen, Lars C., Prasad, Rajendra, Wilson, Samuel H.
Publicado 2010

Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide

por Freudenthal, Bret D., Beard, William A., Perera, Lalith, Shock, David D., Kim, Taejin, Schlick, Tamar, Wilson, Samuel H.
Publicado 2014

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

por Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Publicado 2019

Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

por Kirby, Thomas W., DeRose, Eugene F., Beard, William A., Shock, David D., Wilson, Samuel H., London, Robert E.
Publicado 2014

Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis

por DeRose, Eugene F, Kirby, Thomas W, Mueller, Geoffrey A, Beard, William A, Wilson, Samuel H, London, Robert E
Publicado 2018

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

por Dorjsuren, Dorjbal, Wilson, David M., Beard, William A., McDonald, John P., Austin, Christopher P., Woodgate, Roger, Wilson, Samuel H., Simeonov, Anton
Publicado 2009

Transition State in DNA Polymerase β Catalysis: Rate-Limiting Chemistry Altered by Base-Pair Configuration

por Oertell, Keriann, Chamberlain, Brian T., Wu, Yue, Ferri, Elena, Kashemirov, Boris A., Beard, William A., Wilson, Samuel H., McKenna, Charles E., Goodman, Myron F.
Publicado 2014