Innovative considerations on a phase 2a dose-finding strategy using Bayesian methods and MCP-MOD

por Bedding, Alun, Zhou, Julian
Publicado 2015

Clinical trial protocol for TRANSFORM-UK: A therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension

por Hernández-Sánchez, Jules, Harlow, Louise, Church, Colin, Gaine, Sean, Knightbridge, Emily, Bunclark, Kate, Gor, Dee, Bedding, Alun, Morrell, Nicholas, Corris, Paul, Toshner, Mark
Publicado 2017

How to design a dose-finding study using the continual reassessment method

por Wheeler, Graham M., Mander, Adrian P., Bedding, Alun, Brock, Kristian, Cornelius, Victoria, Grieve, Andrew P., Jaki, Thomas, Love, Sharon B., Odondi, Lang’o, Weir, Christopher J., Yap, Christina, Bond, Simon J.
Publicado 2019

SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol

por Espinasse, Aude, Solovyeva, Olga, Dimairo, Munyaradzi, Weir, Christopher, Jaki, Thomas, Mander, Adrian, Kightley, Andrew, Evans, Jeffry, Lee, Shing, Bedding, Alun, Hopewell, Sally, Rantell, Khadija, Liu, Rong, Chan, An-Wen, De Bono, Johann, Yap, Christina
Publicado 2023

Adaptive designs in clinical trials: why use them, and how to run and report them

por Pallmann, Philip, Bedding, Alun W., Choodari-Oskooei, Babak, Dimairo, Munyaradzi, Flight, Laura, Hampson, Lisa V., Holmes, Jane, Mander, Adrian P., Odondi, Lang’o, Sydes, Matthew R., Villar, Sofía S., Wason, James M. S., Weir, Christopher J., Wheeler, Graham M., Yap, Christina, Jaki, Thomas
Publicado 2018

Early phase clinical trials extension to guidelines for the content of statistical analysis plans

por Homer, Victoria, Yap, Christina, Bond, Simon, Holmes, Jane, Stocken, Deborah, Walker, Katrina, Robinson, Emily J, Wheeler, Graham, Brown, Sarah, Hinsley, Samantha, Schipper, Matthew, Weir, Christopher J, Rantell, Khadija, Prior, Thomas, Yu, Ly-Mee, Kirkpatrick, John, Bedding, Alun, Gamble, Carrol, Gaunt, Piers
Publicado 2022

Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study

por Solovyeva, Olga, Dimairo, Munyaradzi, Weir, Christopher J., Hee, Siew Wan, Espinasse, Aude, Ursino, Moreno, Patel, Dhrusti, Kightley, Andrew, Hughes, Sarah, Jaki, Thomas, Mander, Adrian, Evans, Thomas R. Jeffry, Lee, Shing, Hopewell, Sally, Rantell, Khadija Rerhou, Chan, An-Wen, Bedding, Alun, Stephens, Richard, Richards, Dawn, Roberts, Lesley, Kirkpatrick, John, de Bono, Johann, Yap, Christina
Publicado 2023

A computational framework for complex disease stratification from multiple large-scale datasets

por De Meulder, Bertrand, Lefaudeux, Diane, Bansal, Aruna T., Mazein, Alexander, Chaiboonchoe, Amphun, Ahmed, Hassan, Balaur, Irina, Saqi, Mansoor, Pellet, Johann, Ballereau, Stéphane, Lemonnier, Nathanaël, Sun, Kai, Pandis, Ioannis, Yang, Xian, Batuwitage, Manohara, Kretsos, Kosmas, van Eyll, Jonathan, Bedding, Alun, Davison, Timothy, Dodson, Paul, Larminie, Christopher, Postle, Anthony, Corfield, Julie, Djukanovic, Ratko, Chung, Kian Fan, Adcock, Ian M., Guo, Yi-Ke, Sterk, Peter J., Manta, Alexander, Rowe, Anthony, Baribaud, Frédéric, Auffray, Charles
Publicado 2018