Biomarker development for immuno-oncology and cancer immunotherapy: simultaneous digital counting of nucleic-acids and proteins at 800-plex

por Cesano, Alessandra, Beechem, Joseph M
Publicado 2015

An information theoretic approach to detecting spatially varying genes

por Jones, Daniel C., Danaher, Patrick, Kim, Youngmi, Beechem, Joseph M., Gottardo, Raphael, Newell, Evan W.
Publicado 2023

Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data

por Danaher, Patrick, Kim, Youngmi, Nelson, Brenn, Griswold, Maddy, Yang, Zhi, Piazza, Erin, Beechem, Joseph M.
Publicado 2022

CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma

por Khunger, Arjun, Piazza, Erin, Warren, Sarah, Smith, Thomas H., Ren, Xing, White, Andrew, Elliott, Nathan, Cesano, Alessandra, Beechem, Joseph M., Kirkwood, John M., Tarhini, Ahmad A.
Publicado 2021

Preliminary validation of nCounter PanCancer immune profiling of FFPE slides and pbmc in CITN-05, a CITN study of the immunological effects of an IDO1 inhibitor in patients with ov...

por Dennis, Lucas, Fling, Steven P, Beechem, Joseph M, Danaher, Patrick, D'Amico, Leonard, Disis, Mary, Elliott, Nathan, Geller, Melissa, Jacquemont, Celine, Kussick, Steven, Shine, Richard, Odunsi, Kunle
Publicado 2015

Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles

por Bonnett, Shilah A., Rosenbloom, Alyssa B., Ong, Giang T., Conner, Mark, Rininger, Aric B.E., Newhouse, Daniel, New, Felicia, Phan, Chi Q., Ilcisin, Saskia, Sato, Hiromi, Lyssand, John S., Geiss, Gary, Beechem, Joseph M.
Publicado 2023

Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling

por Zimmerman, Stephanie M., Fropf, Robin, Kulasekara, Bridget R., Griswold, Maddy, Appelbe, Oliver, Bahrami, Arya, Boykin, Rich, Buhr, Derek L., Fuhrman, Kit, Hoang, Margaret L., Huynh, Quoc, Isgur, Lesley, Klock, Andrew, Kutchma, Alecksandr, Lasley, Alexa E., Liang, Yan, McKay-Fleisch, Jill, Nelson, Jeffrey S., Nguyen, Karen, Piazza, Erin, Rininger, Aric, Zollinger, Daniel R., Rhodes, Michael, Beechem, Joseph M.
Publicado 2022

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

por Shiau, Carina, Cao, Jingyi, Gregory, Mark T., Gong, Dennis, Yin, Xunqin, Cho, Jae-Won, Wang, Peter L., Su, Jennifer, Wang, Steven, Reeves, Jason W., Kim, Tae Kyung, Kim, Youngmi, Guo, Jimmy A., Lester, Nicole A., Schurman, Nathan, Barth, Jamie L., Weissleder, Ralph, Jacks, Tyler, Qadan, Motaz, Hong, Theodore S., Wo, Jennifer Y., Roberts, Hannah, Beechem, Joseph M., Castillo, Carlos Fernandez-del, Mino-Kenudson, Mari, Ting, David T., Hemberg, Martin, Hwang, William L.
Publicado 2023