Central Versus Peripheral Drug Exposure Ratio, a Key Differentiator for Siponimod Over Fingolimod?

por Bigaud, Marc, Ramseier, Pamela, Tisserand, Sarah, Lang, Meike, Urban, Beatrice, Beerli, Christian, Karlsson, Göril
Publicado 2023

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

por Lea, Simon R, Metcalfe, Hannah J, Plumb, Jonathan, Beerli, Christian, Poll, Chris, Singh, Dave, Abbott-Banner, Katharine H
Publicado 2016

Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights

por Bigaud, Marc, Rudolph, Bettina, Briard, Emmanuelle, Beerli, Christian, Hofmann, Andreas, Hermes, Erwin, Muellershausen, Florian, Schubart, Anna, Gardin, Anne
Publicado 2021

Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis

por Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette
Publicado 2013

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

por Bigaud, Marc, Dincer, Zuhal, Bollbuck, Birgit, Dawson, Janet, Beckmann, Nicolau, Beerli, Christian, Fishli-Cavelti, Gina, Nahler, Michaela, Angst, Daniela, Janser, Philipp, Otto, Heike, Rosner, Elisabeth, Hersperger, Rene, Bruns, Christian, Quancard, Jean
Publicado 2016

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

por Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas
Publicado 2020

Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models

por Dietrich, Michael, Hecker, Christina, Martin, Elodie, Langui, Dominique, Gliem, Michael, Stankoff, Bruno, Lubetzki, Catherine, Gruchot, Joel, Göttle, Peter, Issberner, Andrea, Nasiri, Milad, Ramseier, Pamela, Beerli, Christian, Tisserand, Sarah, Beckmann, Nicolau, Shimshek, Derya, Petzsch, Patrick, Akbar, David, Levkau, Bodo, Stark, Holger, Köhrer, Karl, Hartung, Hans-Peter, Küry, Patrick, Meuth, Sven Günther, Bigaud, Marc, Zalc, Bernard, Albrecht, Philipp
Publicado 2022