Remodeling the Tumor Myeloid Landscape to Enhance Antitumor Antibody Immunotherapies

por Hussain, Khiyam, Cragg, Mark S., Beers, Stephen A.
Publicado 2021

The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer

por Blyth, Rhianna Rachael Romany, Birts, Charles N., Beers, Stephen A.
Publicado 2023

The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma

por Smith, Hannah L., Beers, Stephen A., Gray, Juliet C., Kanczler, Janos M.
Publicado 2020

Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment

por Liu, Rena, Oldham, Robert J., Teal, Emma, Beers, Stephen A., Cragg, Mark S.
Publicado 2020

Tri-Lineage Differentiation Potential of Osteosarcoma Cell Lines and Human Bone Marrow Stromal Cells from Different Anatomical Locations

por Smith, Hannah L., Gray, Juliet C., Beers, Stephen A., Kanczler, Janos M.
Publicado 2023

Obesity Is Associated with Immunometabolic Changes in Adipose Tissue That May Drive Treatment Resistance in Breast Cancer: Immune-Metabolic Reprogramming and Novel Therapeutic Stra...

por Savva, Constantinos, Copson, Ellen, Johnson, Peter W. M., Cutress, Ramsey I., Beers, Stephen A.
Publicado 2023

Activation of GABA(A) receptors inhibits T cell proliferation

por Sparrow, Emma L., James, Sonya, Hussain, Khiyam, Beers, Stephen A., Cragg, Mark S., Bogdanov, Yury D.
Publicado 2021

Developing a 3D B Cell Lymphoma Culture System to Model Antibody Therapy

por Foxall, Russell, Narang, Priyanka, Glaysher, Bridget, Hub, Elin, Teal, Emma, Coles, Mark C., Ashton-Key, Margaret, Beers, Stephen A., Cragg, Mark S.
Publicado 2021

Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells

por Spear, Sarah, Candido, Juliana B., McDermott, Jacqueline R., Ghirelli, Cristina, Maniati, Eleni, Beers, Stephen A., Balkwill, Frances R., Kocher, Hemant M., Capasso, Melania
Publicado 2019

Cyclophosphamide depletes tumor infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma

por Webb, Emily R., Moreno-Vincente, Julia, Easton, Alistair, Lanati, Silvia, Taylor, Martin, James, Sonya, Williams, Emily L., English, Vikki, Penfold, Chris, Beers, Stephen A., Gray, Juliet C.
Publicado 2022

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells

por Papadakis, Emmanouil, Robson, Natalia, Yeomans, Alison, Bailey, Sarah, Laversin, Stephanie, Beers, Stephen, Sayan, A. Emre, Ashton-Key, Margaret, Schwaiger, Stefan, Stuppner, Hermann, Troppmair, Jakob, Packham, Graham, Cutress, Ramsey
Publicado 2016

On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

por Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.
Publicado 2021

Immune characterization of pre-clinical murine models of neuroblastoma

por Webb, Emily R., Lanati, Silvia, Wareham, Carol, Easton, Alistair, Dunn, Stuart N., Inzhelevskaya, Tatyana, Sadler, Freja M., James, Sonya, Ashton-Key, Margaret, Cragg, Mark S., Beers, Stephen A., Gray, Juliet C.
Publicado 2020

The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells

por Banerjee, Arindam, Arvinrad, Pardis, Darley, Matthew, Laversin, Stéphanie A., Parker, Rachel, Rose-Zerilli, Matthew J.J., Townsend, Paul A., Cutress, Ramsey I., Beers, Stephen A., Houghton, Franchesca D., Birts, Charles N., Blaydes, Jeremy P.
Publicado 2018

Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma

por Birts, Charles N., Savva, Constantinos, Laversin, Stéphanie A., Lefas, Alicia, Krishnan, Jamie, Schapira, Aron, Ashton-Key, Margaret, Crispin, Max, Johnson, Peter W. M., Blaydes, Jeremy P., Copson, Ellen, Cutress, Ramsey I., Beers, Stephen A.
Publicado 2022

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering

por Heckel, Franziska, Turaj, Anna H., Fisher, Hayden, Chan, H. T. Claude, Marshall, Michael J. E., Dadas, Osman, Penfold, Christine A., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Alvarado, Diego, Tews, Ivo, Keler, Tibor, Beers, Stephen A., Cragg, Mark S., Lim, Sean H.
Publicado 2022

Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free surviva...

por Zeidan, Bashar, Manousopoulou, Antigoni, Garay-Baquero, Diana J., White, Cory H., Larkin, Samantha E. T., Potter, Kathleen N., Roumeliotis, Theodoros I., Papachristou, Evangelia K., Copson, Ellen, Cutress, Ramsey I., Beers, Stephen A., Eccles, Diana, Townsend, Paul A., Garbis, Spiros D.
Publicado 2018

Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments

por Moreno-Vicente, Julia, Willoughby, Jane E, Taylor, Martin C, Booth, Steven G, English, Vikki L, Williams, Emily L, Penfold, Christine A, Mockridge, C Ian, Inzhelevskaya, Tatyana, Kim, Jinny, Chan, H T Claude, Cragg, Mark S, Gray, Juliet C, Beers, Stephen A
Publicado 2022

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms

por Simpson, Alexander P., Roghanian, Ali, Oldham, Robert J., Chan, H.T. Claude, Penfold, Christine A., Kim, Hyung J., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Bogdanov, Yury D., James, Sonya, Tutt, Alison L., Rycroft, Daniel, Morley, Peter, Dahal, Lekh N., Teige, Ingrid, Frendeus, Björn, Beers, Stephen A., Cragg, Mark S.
Publicado 2022

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

por White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane, Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A., Glennie, Martin J.
Publicado 2015