It takes two to tango, and the right music: Synergistic drug combinations with cell-cycle phase-dependent sensitivities

por Lieftink, Cor, Beijersbergen, Roderick L
Publicado 2021

The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality

por Evers, Bastiaan, Bernards, Rene, Beijersbergen, Roderick L
Publicado 2014

The Histone Demethylase Jarid1b (Kdm5b) Is a Novel Component of the Rb Pathway and Associates with E2f-Target Genes in MEFs during Senescence

por Nijwening, Jeroen H., Geutjes, Ernst-Jan, Bernards, Rene, Beijersbergen, Roderick L.
Publicado 2011

A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway

por Mullenders, Jasper, Fabius, Armida W. M., Madiredjo, Mandy, Bernards, René, Beijersbergen, Roderick L.
Publicado 2009

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

por Barrangou, Rodolphe, Birmingham, Amanda, Wiemann, Stefan, Beijersbergen, Roderick L., Hornung, Veit, Smith, Anja van Brabant
Publicado 2015

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling

por Kuiken, Hendrik J, Egan, David A, Laman, Heike, Bernards, Rene, Beijersbergen, Roderick L, Dirac, Annette M
Publicado 2012

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

por Iskit, Sedef, Lieftink, Cor, Halonen, Pasi, Shahrabi, Aida, Possik, Patricia A., Beijersbergen, Roderick L., Peeper, Daniel S.
Publicado 2016

A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways

por de Rooij, Martin F. M., Thus, Yvonne J., Swier, Nathalie, Beijersbergen, Roderick L., Pals, Steven T., Spaargaren, Marcel
Publicado 2022

Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen

por Schepers, Arnout, Jochems, Fleur, Lieftink, Cor, Wang, Liqin, Pogacar, Ziva, Leite de Oliveira, Rodrigo, De Conti, Giulia, Beijersbergen, Roderick L., Bernards, Rene
Publicado 2021

A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

por Vizoso, Miguel, E. J. Pritchard, Colin, Bombardelli, Lorenzo, van den Broek, Bram, Krimpenfort, Paul, Beijersbergen, Roderick L., Jalink, Kees, van Rheenen, Jacco
Publicado 2022

High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells

por Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., van Leeuwen, Ester M.M., Kuijpers, Taco W.
Publicado 2019

The RECQL helicase prevents replication fork collapse during replication stress

por Benedict, Bente, van Bueren, Marit AE, van Gemert, Frank PA, Lieftink, Cor, Guerrero Llobet, Sergi, van Vugt, Marcel ATM, Beijersbergen, Roderick L, te Riele, Hein
Publicado 2020

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer

por Papadakis, Andreas I, Sun, Chong, Knijnenburg, Theo A, Xue, Yibo, Grernrum, Wipawadee, Hölzel, Michael, Nijkamp, Wouter, Wessels, Lodewyk FA, Beijersbergen, Roderick L, Bernards, Rene, Huang, Sidong
Publicado 2015

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

por Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J. D., Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L., Wessels, Lodewyk F. A., Rothstein, Rodney, Bernards, René
Publicado 2018

Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

por Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J. D., Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L., Wessels, Lodewyk F. A., Rothstein, Rodney, Bernards, René
Publicado 2021

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities

por Serresi, Michela, Siteur, Bjorn, Hulsman, Danielle, Company, Carlos, Schmitt, Matthias J., Lieftink, Cor, Morris, Ben, Cesaroni, Matteo, Proost, Natalie, Beijersbergen, Roderick L., van Lohuizen, Maarten, Gargiulo, Gaetano
Publicado 2018

Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation

por Thus, Yvonne J., de Rooij, Martin F.M., Swier, Nathalie, Beijersbergen, Roderick L., Guikema, Jeroen E.J., Kersten, Marie-José, Eldering, Eric, Pals, Steven T., Kater, Arnon P., Spaargaren, Marcel
Publicado 2022

The Cancer SENESCopedia: A delineation of cancer cell senescence

por Jochems, Fleur, Thijssen, Bram, De Conti, Giulia, Jansen, Robin, Pogacar, Ziva, Groot, Kelvin, Wang, Liqin, Schepers, Arnout, Wang, Cun, Jin, Haojie, Beijersbergen, Roderick L., Leite de Oliveira, Rodrigo, Wessels, Lodewyk F.A., Bernards, René
Publicado 2021

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling

por Brunen, Diede, García-Barchino, María José, Malani, Disha, Basheer, Noorjahan Jagalur, Lieftink, Cor, Beijersbergen, Roderick L., Murumägi, Astrid, Porkka, Kimmo, Wolf, Maija, Zwaan, C. Michel, Fornerod, Maarten, Kallioniemi, Olli, Martínez-Climent, José Ángel, Bernards, René
Publicado 2016

Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancer

por Zhou, Yangyang, Wang, Siying, Wu, Wei, Ling, Jing, Li, Haoyu, Jia, Qi, Zheng, Jiaojiao, Zheng, Xingling, Yu, Ruobing, Wu, Qiangxin, Shi, Yaoping, Lieftink, Cor, Beijersbergen, Roderick L., Yuan, Shengxian, Bernards, René, Jin, Haojie, Qin, Wenxin
Publicado 2022