Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation

por Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Publicado 2023

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

por Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Publicado 2021

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation

por Xia, Yuxing, Bell, Brach M., Kim, Justin D., Giasson, Benoit I.
Publicado 2023

Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology

por Paterno, Giavanna, Bell, Brach M., Gorion, Kimberly-Marie M., Prokop, Stefan, Giasson, Benoit I.
Publicado 2022

Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites

por Paterno, Giavanna, Torrellas, Jose, Bell, Brach M., Gorion, Kimberly-Marie M., Quintin, Stephan S., Hery, Gabriela P., Prokop, Stefan, Giasson, Benoit I.
Publicado 2023

Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114

por Quintin, Stephan, Lloyd, Grace M., Paterno, Giavanna, Xia, Yuxing, Sorrentino, Zachary, Bell, Brach M., Gorion, Kimberly-Marie, Lee, Edward B., Prokop, Stefan, Giasson, Benoit I.
Publicado 2023

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

por Lloyd, Grace M., Long, Brooke, Quintin, Stephan, Sorrentino, Zachary A., Gorion, Kimberly-Marie M., Bell, Brach M., Carrillo, Denise, Sullivan, Patrick, Borchelt, David, Giasson, Benoit I.
Publicado 2023

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

por Xia, Yuxing, Prokop, Stefan, Gorion, Kimberly-Marie M., Kim, Justin D., Sorrentino, Zachary A., Bell, Brach M., Manaois, Alyssa N., Chakrabarty, Paramita, Davies, Peter, Giasson, Benoit I.
Publicado 2020

Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice

por Xia, Yuxing, Prokop, Stefan, Bell, Brach M., Gorion, Kimberly-Marie M., Croft, Cara L., Nasif, Lith, Xu, Guilian, Riffe, Cara J., Manaois, Alyssa N., Strang, Kevin H., Quintin, Stephan S., Paterno, Giavanna, Tansey, Malú Gámez, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.
Publicado 2022