Mesothelin's minimal MUC16 binding moiety converts TR3 into a potent cancer therapeutic via hierarchical binding events at the plasma membrane

por Su, Yang, Tatzel, Katharina, Wang, Xuejun, Belt, Brian, Binder, Pratibha, Kuroki, Lindsay, Powell, Matthew A., Mutch, David G., Hawkins, William G., Spitzer, Dirk
Publicado 2016

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3

por Garg, Gunjal, Gibbs, Jesse, Belt, Brian, Powell, Matthew A, Mutch, David G, Goedegebuure, Peter, Collins, Lynne, Piwnica-Worms, David, Hawkins, William G, Spitzer, Dirk
Publicado 2014

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes

por Connolly, Kelli A., Belt, Brian A., Figueroa, Nathania M., Murthy, Aditi, Patel, Ankit, Kim, Minsoo, Lord, Edith M., Linehan, David C., Gerber, Scott A.
Publicado 2016

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

por Panni, Roheena Z., Sanford, Dominic E., Belt, Brian A., Mitchem, Jonathan B., Worley, Lori A., Goetz, Brian D., Mukherjee, Pinku, Wang-Gillam, Andrea, Link, Daniel C., DeNardo, David G., Goedegebuure, S. Peter, Linehan, David C.
Publicado 2014

CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models

por Ye, Jian, Gavras, Nicholas W, Keeley, David C, Hughson, Angela L, Hannon, Gary, Vrooman, Tara G, Lesch, Maggie L, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Eyles, Jim, Gerber, Scott A
Publicado 2023

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer

por Ye, Jian, Mills, Bradley N, Qin, Shuyang S, Garrett-Larsen, Jesse, Murphy, Joseph D, Uccello, Taylor P, Han, Booyeon J, Vrooman, Tara G, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Gerber, Scott A
Publicado 2022

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of meta...

por Noel, Marcus, O’Reilly, Eileen M., Wolpin, Brian M., Ryan, David P., Bullock, Andrea J., Britten, Carolyn D., Linehan, David C., Belt, Brian A., Gamelin, Eric C., Ganguly, Bishu, Yin, Donghua, Joh, Tenshang, Jacobs, Ira A., Taylor, Carrie T., Lowery, Maeve A.
Publicado 2019

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

por Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.
Publicado 2016

Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcino...

por Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Publicado 2018

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

por Mills, Bradley N., Connolly, Kelli A., Ye, Jian, Murphy, Joseph D., Uccello, Taylor P., Han, Booyeon J., Zhao, Tony, Drage, Michael G., Murthy, Aditi, Qiu, Haoming, Patel, Ankit, Figueroa, Nathania M., Johnston, Carl J., Prieto, Peter A., Egilmez, Nejat K., Belt, Brian A., Lord, Edith M., Linehan, David C., Gerber, Scott A.
Publicado 2019

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity

por Ruffolo, Luis I, Jackson, Katherine M, Kuhlers, Peyton C, Dale, Benjamin S, Figueroa Guilliani, Nathania M, Ullman, Nicholas A, Burchard, Paul R, Qin, Shuyang S, Juviler, Peter G, Keilson, Jessica Millian, Morrison, Ashley B, Georger, Mary, Jewell, Rachel, Calvi, Laura M, Nywening, Timothy M, O'Dell, Michael R, Hezel, Aram F, De Las Casas, Luis, Lesinski, Gregory B, Yeh, Jen Jen, Hernandez-Alejandro, Roberto, Belt, Brian A, Linehan, David C
Publicado 2022