FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

por Lee, Yun-Kyoung, Diaz, Bryan, Deroose, Marianne, Lee, Samuel X., Belvedere, Sandro, Accili, Domenico, Leibel, Rudolph L., Lin, Hua V.
Publicado 2021

Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

por Lee, Yun-Kyoung, Du, Wen, Nie, Yaohui, Diaz, Bryan, Sultana, Nishat, Kitamoto, Takumi, Leibel, Rudolph L., Accili, Domenico, Belvedere, Sandro
Publicado 2022

Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes

por Kitamoto, Takumi, Lee, Yun-Kyoung, Sultana, Nishat, Watanabe, Hitoshi, McKimpson, Wendy M., Du, Wen, Fan, Jason, Diaz, Bryan, Lin, Hua V., Leibel, Rudolph L., Belvedere, Sandro, Accili, Domenico
Publicado 2022

Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals

por Du, Wen, Wang, Junqiang, Kuo, Taiyi, Wang, Liheng, McKimpson, Wendy M., Son, Jinsook, Watanabe, Hitoshi, Kitamoto, Takumi, Lee, Yunkyoung, Creusot, Remi J., Ratner, Lloyd E., McCune, Kasi, Chen, Ya-Wen, Grubbs, Brendan H., Thornton, Matthew E., Fan, Jason, Sultana, Nishat, Diaz, Bryan S., Balasubramanian, Iyshwarya, Gao, Nan, Belvedere, Sandro, Accili, Domenico
Publicado 2022

A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas

por Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J., Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V., Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V., Cantley, Lewis C., Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A., Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye
Publicado 2022