Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

por Villa, Elodie, Ali, Eunus S., Sahu, Umakant, Ben-Sahra, Issam
Publicado 2019

SGLT2 Inhibition on Cardiac Mitochondrial Function: Searching for a Sweet Spot

por Sawicki, Konrad Teodor, Ben‐Sahra, Issam, McNally, Elizabeth M.
Publicado 2021

mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

por Ben-Sahra, Issam, Ricoult, Stephane, Howell, Jessica, Asara, John, Manning, Brendan
Publicado 2014

The TSC-mTOR pathway regulates macrophage polarization

por Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Sabatini, David M., Manning, Brendan D., Horng, Tiffany
Publicado 2013

Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

por Robert, Guillaume, Ben Sahra, Issam, Puissant, Alexandre, Colosetti, Pascal, Belhacene, Nathalie, Gounon, Pierre, Hofman, Paul, Bost, Fréderic, Cassuto, Jill-Patrice, Auberger, Patrick
Publicado 2009

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis

por Liu, Xue-Song, Haines, Jenna E., Mehanna, Elie K., Genet, Matthew D., Ben-Sahra, Issam, Asara, John M., Manning, Brendan D., Yuan, Zhi-Min
Publicado 2014

The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression

por Khan, Md. Wasim, Terry, Alexander R., Priyadarshini, Medha, Ilievski, Vladimir, Farooq, Zeenat, Guzman, Grace, Cordoba-Chacon, Jose, Ben-Sahra, Issam, Wicksteed, Barton, Layden, Brian T.
Publicado 2022

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

por Regazzetti, Claire, Peraldi, Pascal, Grémeaux, Thierry, Najem-Lendom, Rosanna, Ben-Sahra, Issam, Cormont, Mireille, Bost, Frédéric, Le Marchand-Brustel, Yannick, Tanti, Jean-François, Giorgetti-Peraldi, Sophie
Publicado 2009

Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

por Sawicki, Konrad T., Ning, Hongyan, Allen, Norrina B., Carnethon, Mercedes R., Wallia, Amisha, Otvos, James D., Ben-Sahra, Issam, McNally, Elizabeth M., Snell-Bergeon, Janet K., Wilkins, John T.
Publicado 2023

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

por Byles, Vanessa, Cormerais, Yann, Kalafut, Krystle, Barrera, Victor, Hughes Hallett, James E., Sui, Shannan Ho, Asara, John M., Adams, Christopher M., Hoxhaj, Gerta, Ben-Sahra, Issam, Manning, Brendan D.
Publicado 2021

ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice

por Kouzu, Hidemichi, Tatekoshi, Yuki, Chang, Hsiang-Chun, Shapiro, Jason S., McGee, Warren A., De Jesus, Adam, Ben-Sahra, Issam, Arany, Zoltan, Leor, Jonathan, Chen, Chunlei, Blackshear, Perry J., Ardehali, Hossein
Publicado 2022

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

por Srivastava, Shashank, Sahu, Umakant, Zhou, Yalu, Hogan, Ann K., Sathyan, Kizhakke Mattada, Bodner, Justin, Huang, Jiehuan, Wong, Kelvin A., Khalatyan, Natalia, Savas, Jeffrey N., Ntziachristos, Panagiotis, Ben-Sahra, Issam, Foltz, Daniel R.
Publicado 2021

Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations

por Zhao, Zibo, Cao, Kaixiang, Watanabe, Jun, Philips, Cassandra N., Zeidner, Jacob M., Ishi, Yukitomo, Wang, Qixuan, Gold, Sarah R., Junkins, Katherine, Bartom, Elizabeth T., Yue, Feng, Chandel, Navdeep S., Hashizume, Rintaro, Ben-Sahra, Issam, Shilatifard, Ali
Publicado 2023

ASCT2 is the primary serine transporter in cancer cells

por Conger, Kelly O., Chidley, Christopher, Ozgurses, Mete Emir, Zhao, Huiping, Kim, Yumi, Semina, Svetlana E., Burns, Philippa, Rawat, Vipin, Sheldon, Ryan, Ben-Sahra, Issam, Frasor, Jonna, Sorger, Peter K., DeNicola, Gina M., Coloff, Jonathan L.
Publicado 2023

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

por Perrault, Ella N., Shireman, Jack M., Ali, Eunus S., Lin, Peiyu, Preddy, Isabelle, Park, Cheol, Budhiraja, Shreya, Baisiwala, Shivani, Dixit, Karan, James, C. David, Heiland, Dieter H, Ben-Sahra, Issam, Pott, Sebastian, Basu, Anindita, Miska, Jason, Ahmed, Atique U.
Publicado 2023

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

por Lemberg, Kathryn M., Ali, Eunus S., Krecmerova, Marcela, Aguilar, Joanna Marie H., Alt, Jesse, Peters, Diane E., Zhao, Liang, Wu, Ying, Nuha, Naziba, Asara, John M., Staedtke, Verena, Pratilas, Christine A., Majer, Pavel, Rais, Rana, Ben-Sahra, Issam, Slusher, Barbara S.
Publicado 2023

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

por Covarrubias, Anthony J, Aksoylar, Halil Ibrahim, Yu, Jiujiu, Snyder, Nathaniel W, Worth, Andrew J, Iyer, Shankar S, Wang, Jiawei, Ben-Sahra, Issam, Byles, Vanessa, Polynne-Stapornkul, Tiffany, Espinosa, Erika C, Lamming, Dudley, Manning, Brendan D, Zhang, Yijing, Blair, Ian A, Horng, Tiffany
Publicado 2016

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells

por Lam, Hilaire C., Liu, Heng-Jia, Baglini, Christian V., Filippakis, Harilaos, Alesi, Nicola, Nijmeh, Julie, Du, Heng, Lope, Alicia Llorente, Cottrill, Katherine A., Handen, Adam, Asara, John M., Kwiatkowski, David J., Ben-Sahra, Issam, Oldham, William M., Chan, Stephen Y., Henske, Elizabeth P.
Publicado 2017

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

por Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic
Publicado 2017

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

por Soflaee, Mona Hoseini, Kesavan, Rushendhiran, Sahu, Umakant, Tasdogan, Alpaslan, Villa, Elodie, Djabari, Zied, Cai, Feng, Tran, Diem H., Vu, Hieu S., Ali, Eunus S., Rion, Halie, O’Hara, Brendan P., Kelekar, Sherwin, Hallett, James Hughes, Martin, Misty, Mathews, Thomas P., Gao, Peng, Asara, John M., Manning, Brendan D., Ben-Sahra, Issam, Hoxhaj, Gerta
Publicado 2022