New Understanding of β-Cell Heterogeneity and In Situ Islet Function

por Benninger, Richard K.P., Hodson, David J.
Publicado 2018

Small subpopulations of β-cells do not drive islet oscillatory [Ca(2+)] dynamics via gap junction communication

por Dwulet, JaeAnn M., Briggs, Jennifer K., Benninger, Richard K. P.
Publicado 2021

Decreasing Cx36 Gap Junction Coupling Compensates for Overactive K(ATP) Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

por Nguyen, Linda M., Pozzoli, Marina, Hraha, Thomas H., Benninger, Richard K.P.
Publicado 2014

Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models

por St Clair, Joshua R., Ramirez, David, Passman, Samantha, Benninger, Richard K. P.
Publicado 2018

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

por Benninger, Richard K. P., Dorrell, Craig, Hodson, David J., Rutter, Guy A.
Publicado 2018

Decreases in Gap Junction Coupling Recovers Ca(2+) and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise

por Notary, Aleena M., Westacott, Matthew J., Hraha, Thomas H., Pozzoli, Marina, Benninger, Richard K. P.
Publicado 2016

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

por Head, W. Steven, Orseth, Meredith L., Nunemaker, Craig S., Satin, Leslie S., Piston, David W., Benninger, Richard K.P.
Publicado 2012

Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability

por Hraha, Thomas H., Westacott, Matthew J., Pozzoli, Marina, Notary, Aleena M., McClatchey, P. Mason, Benninger, Richard K. P.
Publicado 2014

Dynamic changes in β-cell [Ca(2+)] regulate NFAT activation, gene transcription, and islet gap junction communication

por Miranda, Jose G., Schleicher, Wolfgang E., Wells, Kristen L., Ramirez, David G., Landgrave, Samantha P., Benninger, Richard K.P.
Publicado 2021

Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing

por Shi, Lixue, Wei, Mian, Miao, Yupeng, Qian, Naixin, Shi, Lingyan, Singer, Ruth A., Benninger, Richard K. P., Min, Wei
Publicado 2022

Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes

por Farnsworth, Nikki L., Piscopio, Robert A., Schleicher, Wolfgang E., Ramirez, David G., Miranda, Jose G., Benninger, Richard K. P.
Publicado 2022

Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes

por Ramirez, David G., Abenojar, Eric, Hernandez, Christopher, Lorberbaum, David S., Papazian, Lucine A., Passman, Samantha, Pham, Vinh, Exner, Agata A., Benninger, Richard K. P.
Publicado 2020

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

por Hang, Yan, Yamamoto, Tsunehiko, Benninger, Richard K.P., Brissova, Marcela, Guo, Min, Bush, Will, Piston, David W., Powers, Alvin C., Magnuson, Mark, Thurmond, Debbie C., Stein, Roland
Publicado 2014

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

por Kravets, Vira, Dwulet, JaeAnn M., Schleicher, Wolfgang E., Hodson, David J., Davis, Anna M., Pyle, Laura, Piscopio, Robert A., Sticco-Ivins, Maura, Benninger, Richard K. P.
Publicado 2022

Optogenetic stimulation of cholinergic fibers for the modulation of insulin and glycemia

por Fontaine, Arjun K., Ramirez, David G., Littich, Samuel F., Piscopio, Robert A., Kravets, Vira, Schleicher, Wolfgang E., Mizoguchi, Naoko, Caldwell, John H., Weir, Richard F. ff., Benninger, Richard K. P.
Publicado 2021

Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells

por Zhao, Aizhen, Ohara-Imaizumi, Mica, Brissova, Marcella, Benninger, Richard K.P., Xu, Yanwen, Hao, Yuhan, Abramowitz, Joel, Boulay, Guylain, Powers, Alvin C., Piston, David, Jiang, Meisheng, Nagamatsu, Shinya, Birnbaumer, Lutz, Gu, Guoqiang
Publicado 2010

Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

por Kim, Yong Kyung, Walters, Jay A., Moss, Nicole D., Wells, Kristen L., Sheridan, Ryan, Miranda, Jose G., Benninger, Richard K.P., Pyle, Laura L., O'Brien, Richard M., Sussel, Lori, Davidson, Howard W.
Publicado 2022

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

por Docherty, Fiona M., Riemondy, Kent A., Castro-Gutierrez, Roberto, Dwulet, JaeAnn M., Shilleh, Ali H., Hansen, Maria S., Williams, Shane P.M., Armitage, Lucas H., Santostefano, Katherine E., Wallet, Mark A., Mathews, Clayton E., Triolo, Taylor M., Benninger, Richard K.P., Russ, Holger A.
Publicado 2021