A drug target slim: using gene ontology and gene ontology annotations to navigate protein-ligand target space in ChEMBL

por Mutowo, Prudence, Bento, A. Patrícia, Dedman, Nathan, Gaulton, Anna, Hersey, Anne, Lomax, Jane, Overington, John P.
Publicado 2016

Drug Safety Data Curation and Modeling in ChEMBL: Boxed Warnings and Withdrawn Drugs

por Hunter, Fiona M.I., Bento, A. Patrícia, Bosc, Nicolas, Gaulton, Anna, Hersey, Anne, Leach, Andrew R.
Publicado 2021

A large-scale dataset of in vivo pharmacology assay results

por Hunter, Fiona M. I., L. Atkinson, Francis, Bento, A. Patrícia, Bosc, Nicolas, Gaulton, Anna, Hersey, Anne, Leach, Andrew R.
Publicado 2018

Target-based evaluation of ‘drug-like’ properties and ligand efficiencies

por Leeson, Paul D., Bento, A. Patricia, Gaulton, Anna, Hersey, Anne, Manners, Emma J., Radoux, Chris J., Leach, Andrew R.
Publicado 2021

An open source chemical structure curation pipeline using RDKit

por Bento, A. Patrícia, Hersey, Anne, Félix, Eloy, Landrum, Greg, Gaulton, Anna, Atkinson, Francis, Bellis, Louisa J., De Veij, Marleen, Leach, Andrew R.
Publicado 2020

Linking rare and common disease: mapping clinical disease-phenotypes to ontologies in therapeutic target validation

por Sarntivijai, Sirarat, Vasant, Drashtti, Jupp, Simon, Saunders, Gary, Bento, A. Patrícia, Gonzalez, Daniel, Betts, Joanna, Hasan, Samiul, Koscielny, Gautier, Dunham, Ian, Parkinson, Helen, Malone, James
Publicado 2016

ChEMBL: a large-scale bioactivity database for drug discovery

por Gaulton, Anna, Bellis, Louisa J., Bento, A. Patricia, Chambers, Jon, Davies, Mark, Hersey, Anne, Light, Yvonne, McGlinchey, Shaun, Michalovich, David, Al-Lazikani, Bissan, Overington, John P.
Publicado 2012

A large-scale crop protection bioassay data set

por Gaulton, Anna, Kale, Namrata, van Westen, Gerard J. P., Bellis, Louisa J., Bento, A. Patrícia, Davies, Mark, Hersey, Anne, Papadatos, George, Forster, Mark, Wege, Philip, Overington, John P.
Publicado 2015

The ChEMBL bioactivity database: an update

por Bento, A. Patrícia, Gaulton, Anna, Hersey, Anne, Bellis, Louisa J., Chambers, Jon, Davies, Mark, Krüger, Felix A., Light, Yvonne, Mak, Lora, McGlinchey, Shaun, Nowotka, Michal, Papadatos, George, Santos, Rita, Overington, John P.
Publicado 2014

The ChEMBL database in 2017

por Gaulton, Anna, Hersey, Anne, Nowotka, Michał, Bento, A. Patrícia, Chambers, Jon, Mendez, David, Mutowo, Prudence, Atkinson, Francis, Bellis, Louisa J., Cibrián-Uhalte, Elena, Davies, Mark, Dedman, Nathan, Karlsson, Anneli, Magariños, María Paula, Overington, John P., Papadatos, George, Smit, Ines, Leach, Andrew R.
Publicado 2017

ChEMBL: towards direct deposition of bioassay data

por Mendez, David, Gaulton, Anna, Bento, A Patrícia, Chambers, Jon, De Veij, Marleen, Félix, Eloy, Magariños, María Paula, Mosquera, Juan F, Mutowo, Prudence, Nowotka, Michał, Gordillo-Marañón, María, Hunter, Fiona, Junco, Laura, Mugumbate, Grace, Rodriguez-Lopez, Milagros, Atkinson, Francis, Bosc, Nicolas, Radoux, Chris J, Segura-Cabrera, Aldo, Hersey, Anne, Leach, Andrew R
Publicado 2019

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

por Rasooly, Danielle, Peloso, Gina M., Pereira, Alexandre C., Dashti, Hesam, Giambartolomei, Claudia, Wheeler, Eleanor, Aung, Nay, Ferolito, Brian R., Pietzner, Maik, Farber-Eger, Eric H., Wells, Quinn Stanton, Kosik, Nicole M., Gaziano, Liam, Posner, Daniel C., Bento, A. Patrícia, Hui, Qin, Liu, Chang, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Wilson, Peter W. F., Phillips, Lawrence S., Whittaker, John, Munroe, Patricia B., Petersen, Steffen E., Cho, Kelly, Leach, Andrew R., Magariños, María Paula, Gaziano, John Michael, Langenberg, Claudia, Sun, Yan V., Joseph, Jacob, Casas, Juan P.
Publicado 2023

Open Targets: a platform for therapeutic target identification and validation

por Koscielny, Gautier, An, Peter, Carvalho-Silva, Denise, Cham, Jennifer A., Fumis, Luca, Gasparyan, Rippa, Hasan, Samiul, Karamanis, Nikiforos, Maguire, Michael, Papa, Eliseo, Pierleoni, Andrea, Pignatelli, Miguel, Platt, Theo, Rowland, Francis, Wankar, Priyanka, Bento, A. Patrícia, Burdett, Tony, Fabregat, Antonio, Forbes, Simon, Gaulton, Anna, Gonzalez, Cristina Yenyxe, Hermjakob, Henning, Hersey, Anne, Jupe, Steven, Kafkas, Şenay, Keays, Maria, Leroy, Catherine, Lopez, Francisco-Javier, Magarinos, Maria Paula, Malone, James, McEntyre, Johanna, Munoz-Pomer Fuentes, Alfonso, O'Donovan, Claire, Papatheodorou, Irene, Parkinson, Helen, Palka, Barbara, Paschall, Justin, Petryszak, Robert, Pratanwanich, Naruemon, Sarntivijal, Sirarat, Saunders, Gary, Sidiropoulos, Konstantinos, Smith, Thomas, Sondka, Zbyslaw, Stegle, Oliver, Tang, Y. Amy, Turner, Edward, Vaughan, Brendan, Vrousgou, Olga, Watkins, Xavier, Martin, Maria-Jesus, Sanseau, Philippe, Vamathevan, Jessica, Birney, Ewan, Barrett, Jeffrey, Dunham, Ian
Publicado 2017

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

por Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C, Gaulton, Anna, Posner, Daniel C, Swanson, Sonja A, Ho, Yuk-Lam, Iyengar, Sudha K, Kosik, Nicole M, Vujkovic, Marijana, Gagnon, David R, Bento, A Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E, Prins, Bram P, Di Angelantonio, Emanuele, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E, DuVall, Scott L, Garcon, Helene, Thomann, Lauren O, Zhou, Jin J, Gorman, Bryan R, Huffman, Jennifer E, O'Donnell, Christopher J, Tsao, Philip S, Beckham, Jean C, Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D, Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M, Chang, Kyong-Mi, Sun, Yan V, Joseph, Jacob, Leach, Andrew R, Edwards, Todd L, Cho, Kelly, Gaziano, J Michael, Butterworth, Adam S, Casas, Juan P
Publicado 2021