Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules

por Reddy, Kaalak, Jenquin, Jana R., Cleary, John D., Berglund, J. Andrew
Publicado 2019

Frequent Gain and Loss of Intronic Splicing Regulatory Elements during the Evolution of Vertebrates

por Voelker, Rodger B., Erkelenz, Steffen, Reynoso, Vinicio, Schaal, Heiner, Berglund, J. Andrew
Publicado 2012

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing

por Goers, Emily S., Purcell, Jamie, Voelker, Rodger B., Gates, Devika P., Berglund, J. Andrew
Publicado 2010

The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements

por Cass, Danielle, Hotchko, Rachel, Barber, Paul, Jones, Kimberly, Gates, Devika P, Berglund, J Andrew
Publicado 2011

Conservation of context-dependent splicing activity in distant Muscleblind homologs

por Oddo, Julia C., Saxena, Tanvi, McConnell, Ona L., Berglund, J. Andrew, Wang, Eric T.
Publicado 2016

Identification of motifs that function in the splicing of non-canonical introns

por Murray, Jill I, Voelker, Rodger B, Henscheid, Kristy L, Warf, M Bryan, Berglund, J Andrew
Publicado 2008

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors

por Culler, Stephanie J., Hoff, Kevin G., Voelker, Rodger B., Berglund, J. Andrew, Smolke, Christina D.
Publicado 2010

RNA structure probing to characterize RNA–protein interactions on low abundance pre-mRNA in living cells

por Bubenik, Jodi L., Hale, Melissa, McConnell, Ona, Wang, Eric T., Swanson, Maurice S., Spitale, Robert C., Berglund, J. Andrew
Publicado 2021

An engineered RNA binding protein with improved splicing regulation

por Hale, Melissa A, Richardson, Jared I, Day, Ryan C, McConnell, Ona L, Arboleda, Juan, Wang, Eric T, Berglund, J Andrew
Publicado 2018

Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line

por Bonenfant, Gaston, Meng, Ryan, Shotwell, Carl, Badu, Pheonah, Payne, Anne F., Ciota, Alexander T., Sammons, Morgan A., Berglund, J. Andrew, Pager, Cara T.
Publicado 2020

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

por Mishra, Subodh K., Hicks, Sawyer M., Frias, Jesus A., Vangaveti, Sweta, Nakamori, Masayuki, Cleary, John D., Reddy, Kaalak, Berglund, J. Andrew
Publicado 2023

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

por Hinman, Melissa N., Richardson, Jared I., Sockol, Rose A., Aronson, Eliza D., Stednitz, Sarah J., Murray, Katrina N., Berglund, J. Andrew, Guillemin, Karen
Publicado 2021

Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

por deLorimier, Elaine, Coonrod, Leslie A., Copperman, Jeremy, Taber, Alex, Reister, Emily E., Sharma, Kush, Todd, Peter K., Guenza, Marina G., Berglund, J. Andrew
Publicado 2014

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

por Wagner, Stacey D., Struck, Adam J., Gupta, Riti, Farnsworth, Dylan R., Mahady, Amy E., Eichinger, Katy, Thornton, Charles A., Wang, Eric T., Berglund, J. Andrew
Publicado 2016

Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1

por Davey, Emily E., Légaré, Cécilia, Planco, Lori, Shaughnessy, Sharon, Lennon, Claudia D., Roussel, Marie-Pier, Shorrock, Hannah K., Hung, Man, Cleary, John Douglas, Duchesne, Elise, Berglund, J. Andrew
Publicado 2023

Disease-associated inosine misincorporation into RNA hinders translation

por Schroader, Jacob H, Jones, Lindsey A, Meng, Ryan, Shorrock, Hannah K, Richardson, Jared I, Shaughnessy, Sharon M, Lin, Qishan, Begley, Thomas J, Berglund, J Andrew, Fuchs, Gabriele, Handley, Mark T, Reddy, Kaalak
Publicado 2022

Molecular characterization of myotonic dystrophy fibroblast cell lines for use in small molecule screening

por Jenquin, Jana R., O’Brien, Alana P., Poukalov, Kiril, Lu, Yidan, Frias, Jesus A., Shorrock, Hannah K., Richardson, Jared I., Mazdiyasni, Hormoz, Yang, Hongfen, Huigens, Robert W., Boykin, David, Ranum, Laura P.W., Cleary, John Douglas, Wang, Eric T., Berglund, J. Andrew
Publicado 2022

CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity

por Perez, Barbara A, Shorrock, Hannah K, Banez‐Coronel, Monica, Zu, Tao, Romano, Lisa EL, Laboissonniere, Lauren A, Reid, Tammy, Ikeda, Yoshio, Reddy, Kaalak, Gomez, Christopher M, Bird, Thomas, Ashizawa, Tetsuo, Schut, Lawrence J, Brusco, Alfredo, Berglund, J Andrew, Hasholt, Lis F, Nielsen, Jorgen E, Subramony, SH, Ranum, Laura PW
Publicado 2021