Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model

por Snelder, Nelleke, Hoefman, Sven, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Publicado 2020

Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease

por Hoefman, Sven, Snelder, Nelleke, van Noort, Martijn, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Publicado 2020

Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery‐Åsberg Depression Rating Scale

por Otto, Marije E., Bergmann, Kirsten R., de Kam, Marieke L., Recourt, Kasper, Jacobs, Gabriël E., van Esdonk, Michiel J.
Publicado 2023

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

por Bakker, Charlotte, van der Aart, Jasper, Hart, Ellen P., Klaassen, Erica S., Bergmann, Kirsten R., van Esdonk, Michiel J., Kay, Denis G., Groeneveld, Geert Jan
Publicado 2020

Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations

por Kruizinga, Matthijs D., Zuiker, Rob G. J. A., Bergmann, Kirsten R., Egas, Annelies C., Cohen, Adam F., Santen, Gijs W. E., van Esdonk, Michiel J.
Publicado 2021

First Clinical Study with AP30663 ‐ a K(Ca)2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

por Gal, Pim, Klaassen, Erica S., Bergmann, Kirsten R., Saghari, Mahdi, Burggraaf, Jacobus, Kemme, Michiel J. B., Sylvest, Christina, Sørensen, Ulrik, Bentzen, Bo H., Grunnet, Morten, Diness, Jonas G., Edvardsson, Nils
Publicado 2020

OX40L Inhibition Suppresses KLH‐driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof‐of‐Pharmacology for KY1005

por Saghari, Mahdi, Gal, Pim, Gilbert, Sally, Yateman, Martin, Porter‐Brown, Ben, Brennan, Nuala, Quaratino, Sonia, Wilson, Rosamund, Grievink, Hendrika W., Klaassen, Erica S., Bergmann, Kirsten R., Burggraaf, Jacobus, van Doorn, Martijn B. A., Powell, John, Moerland, Matthijs, Rissmann, Robert
Publicado 2022

A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers

por Berends, Cécile L., Pagan, Lisa, van Esdonk, Michiel J., Klarenbeek, Naomi B., Bergmann, Kirsten R., Moerland, Matthijs, van der Wel, Vincent, de Visser, Saco J., Büller, Hans, de Loos, Frans, de Vries, Wouter S., Waals, Hans, de Leede, Leo G. J., Burggraaf, Jacobus, Kamerling, Ingrid M. C.
Publicado 2021