Toward a New Therapy for Rapidly Aging Children

por Ibrahim, Mohamed X., Bergo, Martin O.
Publicado 2021

Status of treatment strategies for Hutchinson–Gilford progeria syndrome with a focus on prelamin: A posttranslational modification

por Chen, Xue, Yao, Haidong, Andrés, Vicente, Bergo, Martin O., Kashif, Muhammad
Publicado 2022

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

por Griveau, Audrey, Wiel, Clotilde, Ziegler, Dorian V., Bergo, Martin O., Bernard, David
Publicado 2020

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

por Jeong, Angela, Cheng, Shaowu, Zhong, Rui, Bennett, David A., Bergö, Martin O., Li, Ling
Publicado 2021

Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice

por Le Gal, Kristell, Wiel, Clotilde, Ibrahim, Mohamed X., Henricsson, Marcus, Sayin, Volkan I., Bergo, Martin O.
Publicado 2021

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

por Maske, Christopher P., Hollinshead, Michael S., Higbee, Niall C., Bergo, Martin O., Young, Stephen G., Vaux, David J.
Publicado 2003

Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress

por Du, Xingrong, Zeng, Hu, Liu, Shaofeng, Guy, Cliff, Dhungana, Yogesh, Neale, Geoffrey, Bergo, Martin O., Chi, Hongbo
Publicado 2019

ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis

por Kashif, Muhammad, Yao, Haidong, Schmidt, Sarah, Chen, Xue, Truong, Michelle, Tüksammel, Elin, Liu, Yiran, Bergo, Martin O.
Publicado 2023

Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice

por Whisenant, Daniel, Lim, Kayeong, Revêchon, Gwladys, Yao, Haidong, Bergo, Martin O., Machtel, Piotr, Kim, Jin-Soo, Eriksson, Maria
Publicado 2022

Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency

por Yao, Haidong, Chen, Xue, Kashif, Muhammad, Wang, Ting, Ibrahim, Mohamed X., Tüksammel, Elin, Revêchon, Gwladys, Eriksson, Maria, Wiel, Clotilde, Bergo, Martin O.
Publicado 2020

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

por Gul, Nadia, Karlsson, Joakim, Tängemo, Carolina, Linsefors, Sanna, Tuyizere, Samuel, Perkins, Rosie, Ala, Chandu, Zou, Zhiyuan, Larsson, Erik, Bergö, Martin O., Lindahl, Per
Publicado 2019

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

por Griveau, Audrey, Wiel, Clotilde, Le Calvé, Benjamin, Ziegler, Dorian V., Djebali, Sophia, Warnier, Marine, Martin, Nadine, Marvel, Jacqueline, Vindrieux, David, Bergo, Martin O., Bernard, David
Publicado 2018

Lack of RAC1 in macrophages protects against atherosclerosis

por Bandaru, Sashidar, Ala, Chandu, Ekstrand, Matias, Akula, Murali K., Pedrelli, Matteo, Liu, Xi, Bergström, Göran, Håversen, Liliana, Borén, Jan, Bergo, Martin O., Akyürek, Levent M.
Publicado 2020

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut

por Nilton, Anna, Sayin, Volkan I., Zou, Zhiyuan V., Sayin, Sama I., Bondjers, Cecilia, Gul, Nadia, Agren, Pia, Fogelstrand, Per, Nilsson, Ola, Bergo, Martin O., Lindahl, Per
Publicado 2016

Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant Treatment

por Sayin, Volkan I., Nilton, Anna, Ibrahim, Mohamed X., Ågren, Pia, Larsson, Erik, Petit, Marleen M., Hultén, Lillemor Mattsson, Ståhlman, Marcus, Johansson, Bengt R., Bergo, Martin O., Lindahl, Per
Publicado 2013

Tissue architecture delineates field cancerization in BRAF(V600E)-induced tumor development

por Schoultz, Elin, Johansson, Ellen, Moccia, Carmen, Jakubikova, Iva, Ravi, Naveen, Liang, Shawn, Carlsson, Therese, Montelius, Mikael, Patyra, Konrad, Kero, Jukka, Paulsson, Kajsa, Fagman, Henrik, Bergo, Martin O., Nilsson, Mikael
Publicado 2021

Targeting filamin A reduces K-RAS–induced lung adenocarcinomas and endothelial response to tumor growth in mice

por Nallapalli, Rajesh K, Ibrahim, Mohamed X, Zhou, Alex X, Bandaru, Sashidar, Sunkara, Sai Naresh, Redfors, Björn, Pazooki, David, Zhang, Yin, Borén, Jan, Cao, Yihai, Bergo, Martin O, Akyürek, Levent M
Publicado 2012

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

por Kerr, Alastair G., Wang, Zuoneng, Wang, Na, Kwok, Kelvin H. M., Jalkanen, Jutta, Ludzki, Alison, Lecoutre, Simon, Langin, Dominique, Bergo, Martin O., Dahlman, Ingrid, Mim, Carsten, Arner, Peter, Gao, Hui
Publicado 2022

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

por Akula, Murali K., Ibrahim, Mohamed X., Ivarsson, Emil G., Khan, Omar M., Kumar, Israiel T., Erlandsson, Malin, Karlsson, Christin, Xu, Xiufeng, Brisslert, Mikael, Brakebusch, Cord, Wang, Donghai, Bokarewa, Maria, Sayin, Volkan I., Bergo, Martin O.
Publicado 2019

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

por Chen, Xue, Yao, Haidong, Kashif, Muhammad, Revêchon, Gwladys, Eriksson, Maria, Hu, Jianjiang, Wang, Ting, Liu, Yiran, Tüksammel, Elin, Strömblad, Staffan, Ahearn, Ian M, Philips, Mark R, Wiel, Clotilde, Ibrahim, Mohamed X, Bergo, Martin O
Publicado 2021