Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat

por Sánchez-Dengra, Bárbara, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Gonzalez-Alvarez, Marta
Publicado 2021

New In Vitro Methodology for Kinetics Distribution Prediction in the Brain. An Additional Step towards an Animal-Free Approach

por Sánchez-Dengra, Bárbara, González-Álvarez, Isabel, González-Álvarez, Marta, Bermejo, Marival
Publicado 2021

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(®) on the Luminal and Systemic Behavior of Loratadine (BCS Cl...

por Hens, Bart, Bermejo, Marival, Cristofoletti, Rodrigo, Amidon, Gregory E., Amidon, Gordon L.
Publicado 2020

Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood–Brain Barrier in Patients with Glioblastoma

por Sánchez-Dengra, Bárbara, García-Montoya, Elena, González-Álvarez, Isabel, Bermejo, Marival, González-Álvarez, Marta
Publicado 2023

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(®) on the Luminal and Systemic Beha...

por Hens, Bart, Bermejo, Marival, Augustijns, Patrick, Cristofoletti, Rodrigo, Amidon, Gregory E., Amidon, Gordon L.
Publicado 2020

Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System

por delMoral-Sanchez, Jose-Manuel, Gonzalez-Alvarez, Isabel, Gonzalez-Alvarez, Marta, Navarro, Andres, Bermejo, Marival
Publicado 2019

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

por delMoral-Sanchez, Jose-Manuel, Gonzalez-Alvarez, Isabel, Gonzalez-Alvarez, Marta, Navarro-Ruiz, Andres, Bermejo, Marival
Publicado 2020

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

por Bermejo, Marival, Hens, Bart, Dickens, Joseph, Mudie, Deanna, Paixão, Paulo, Tsume, Yasuhiro, Shedden, Kerby, Amidon, Gordon L.
Publicado 2020

In Vivo Predictive Dissolution (IPD) for Carbamazepine Formulations: Additional Evidence Regarding a Biopredictive Dissolution Medium

por Bermejo, Marival, Meulman, Jessica, Davanço, Marcelo Gomes, Carvalho, Patricia de Oliveira, Gonzalez-Alvarez, Isabel, Campos, Daniel Rossi
Publicado 2020

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

por de Souza Teixeira, Leonardo, Vila Chagas, Tatiana, Alonso, Antonio, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Polli, James, Rezende, Kênnia Rocha
Publicado 2020

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

por Gundogdu, Evren, Demir, Emine-Selin, Ekinci, Meliha, Ozgenc, Emre, Ilem-Ozdemir, Derya, Senyigit, Zeynep, Gonzalez-Alvarez, Isabel, Bermejo, Marival
Publicado 2022

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

por Di Meo, Chiara, Martínez-Martínez, Mayte, Coviello, Tommasina, Bermejo, Marival, Merino, Virginia, Gonzalez-Alvarez, Isabel, Gonzalez-Alvarez, Marta, Matricardi, Pietro
Publicado 2018

Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients

por González-Álvarez, Isabel, Sánchez-Dengra, Bárbara, Rodriguez-Galvez, Raquel, Ruiz-Picazo, Alejandro, González-Álvarez, Marta, García-Arieta, Alfredo, Bermejo, Marival
Publicado 2022

Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool

por Figueroa-Campos, Andrés, Sánchez-Dengra, Bárbara, Merino, Virginia, Dahan, Arik, González-Álvarez, Isabel, García-Arieta, Alfredo, González-Álvarez, Marta, Bermejo, Marival
Publicado 2020

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

por Teruel, Adrian H., Gonzalez-Alvarez, Isabel, Bermejo, Marival, Merino, Virginia, Marcos, Maria Dolores, Sancenon, Felix, Gonzalez-Alvarez, Marta, Martinez-Mañez, Ramon
Publicado 2020

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Developm...

por Miranda, Claudia, Ruiz-Picazo, Alejandro, Pomares, Paula, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Gonzalez-Alvarez, Marta, Avdeef, Alex, Cabrera-Pérez, Miguel-Ángel
Publicado 2022

Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products

por Ruiz-Picazo, Alejandro, Colón-Useche, Sarin, Perez-Amorós, Blanca, González-Álvarez, Marta, Molina-Martínez, Irene, González-Álvarez, Isabel, García-Arieta, Alfredo, Bermejo, Marival
Publicado 2019

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers

por Pérez-Sánchez, Almudena, Borrás-Linares, Isabel, Barrajón-Catalán, Enrique, Arráez-Román, David, González-Álvarez, Isabel, Ibáñez, Elena, Segura-Carretero, Antonio, Bermejo, Marival, Micol, Vicente
Publicado 2017

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

por Gonzalez-Alvarez, Isabel, Bermejo, Marival, Tsume, Yasuhiro, Ruiz-Picazo, Alejandro, Gonzalez-Alvarez, Marta, Hens, Bart, Garcia-Arieta, Alfredo, Amidon, Greg E., Amidon, Gordon L.
Publicado 2021

Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS

por Borrás-Linares, Isabel, Herranz-López, María, Barrajón-Catalán, Enrique, Arráez-Román, David, González-Álvarez, Isabel, Bermejo, Marival, Gutiérrez, Alberto Fernández, Micol, Vicente, Segura-Carretero, Antonio
Publicado 2015