Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment: Miniperspective

por Zhao, Yujun, Aguilar, Angelo, Bernard, Denzil, Wang, Shaomeng
Publicado 2014

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

por Aguilar, Angelo, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Bernard, Denzil, Deschamps, Jeffrey R., Wang, Shaomeng
Publicado 2014

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

por Huang, Chang, Bernard, Denzil, Zhu, Jiaqi, Dash, Radha Charan, Chu, Alexander, Knupp, Alec, Hakey, Anna, Hadden, M. Kyle, Garmendia, Antonio, Tang, Young
Publicado 2020

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

por Pedicone, Chiara, Fernandes, Sandra, Matera, Alessandro, Meyer, Shea T., Loh, Stewart, Ha, Jeung-Hoi, Bernard, Denzil, Chisholm, John D., Paolicelli, Rosa Chiara, Kerr, William G.
Publicado 2022

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

por Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng
Publicado 2021

Tetrapyrrolic Pigments from Heme‐ and Chlorophyll Breakdown are Actin‐Targeting Compounds

por Karg, Cornelia A., Wang, Shuaijun, Al Danaf, Nader, Pemberton, Ryan P., Bernard, Denzil, Kretschmer, Maibritt, Schneider, Sabine, Zisis, Themistoklis, Vollmar, Angelika M., Lamb, Don C., Zahler, Stefan, Moser, Simone
Publicado 2021

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

por Zhou, Haibin, Lu, Jianfeng, Liu, Liu, Bernard, Denzil, Yang, Chao-Yie, Fernandez-Salas, Ester, Chinnaswamy, Krishnapriya, Layton, Stephanie, Stuckey, Jeanne, Yu, Qing, Zhou, Weihua, Pan, Zhenqiang, Sun, Yi, Wang, Shaomeng
Publicado 2017

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carbo...

por Aguilar, Angelo, Lu, Jianfeng, Liu, Liu, Du, Ding, Bernard, Denzil, McEachern, Donna, Przybranowski, Sally, Li, Xiaoqin, Luo, Ruijuan, Wen, Bo, Sun, Duxin, Wang, Hengbang, Wen, Jianfeng, Wang, Guangfeng, Zhai, Yifan, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Publicado 2017