Pharmacological validation of targets regulating CD14 during macrophage differentiation

por Jimenez-Duran, Gisela, Luque-Martin, Rosario, Patel, Meghana, Koppe, Emma, Bernard, Sharon, Sharp, Catriona, Buchan, Natalie, Rea, Ceara, de Winther, Menno P.J., Turan, Nil, Angell, Davina, Wells, Christine A., Cousins, Rick, Mander, Palwinder K., Masters, Seth L.
Publicado 2020

Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia

por Furze, Rebecca C., Molnar, Judit, Parr, Nigel J., Ahmad, Faiz, Henry, Yvette, Howe, David, Singh, Rajendra, Toal, Martin, Bassil, Anna K., Bernard, Sharon G., Davis, Robert P., Gibson, Adele, Maller, N. Claire, Sharp, Catriona, Tough, David F., Prinjha, Rab K., Lewis, Huw D.
Publicado 2022

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

por Luque-Martin, Rosario, Van den Bossche, Jan, Furze, Rebecca C., Neele, Annette E., van der Velden, Saskia, Gijbels, Marion J.J., van Roomen, Cindy P.P.A., Bernard, Sharon G., de Jonge, Wouter J., Rioja, Inmaculada, Prinjha, Rab K., Lewis, Huw D., Mander, Palwinder K., de Winther, Menno P.J.
Publicado 2019