Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype

por Bhattacharyya, Sanchari, Bershtein, Shimon, Adkar, Bharat V, Woodard, Jaie, Shakhnovich, Eugene I
Publicado 2021

Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains

por Kleiner, Daniel, Shapiro Tuchman, Ziva, Shmulevich, Fannia, Shahar, Anat, Zarivach, Raz, Kosloff, Mickey, Bershtein, Shimon
Publicado 2022

Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

por Bhattacharyya, Sanchari, Bershtein, Shimon, Yan, Jin, Argun, Tijda, Gilson, Amy I, Trauger, Sunia A, Shakhnovich, Eugene I
Publicado 2016

SAMase of Bacteriophage T3 Inactivates Escherichia coli’s Methionine S-Adenosyltransferase by Forming Heteropolymers

por Simon-Baram, Hadas, Kleiner, Daniel, Shmulevich, Fannia, Zarivach, Raz, Zalk, Ran, Tang, Huayuan, Ding, Feng, Bershtein, Shimon
Publicado 2021

A High‐Throughput Continuous Spectroscopic Assay to Measure the Activity of Natural Product Methyltransferases

por Simon‐Baram, Hadas, Roth, Steffen, Niedermayer, Christina, Huber, Patricia, Speck, Melanie, Diener, Julia, Richter, Michael, Bershtein, Shimon
Publicado 2022

The Fitness Effects of Codon Composition of the Horizontally Transferred Antibiotic Resistance Genes Intensify at Sub-lethal Antibiotic Levels

por Shaferman, Michael, Gencel, Melis, Alon, Noga, Alasad, Khawla, Rotblat, Barak, Serohijos, Adrian W R, Alfonta, Lital, Bershtein, Shimon
Publicado 2023

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria

por Bershtein, Shimon, Serohijos, Adrian W. R., Bhattacharyya, Sanchari, Manhart, Michael, Choi, Jeong-Mo, Mu, Wanmeng, Zhou, Jingwen, Shakhnovich, Eugene I.
Publicado 2015

Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning

por Galai, Geut, Ben-David, Hila, Levin, Liron, Orth, Martin F., Grünewald, Thomas G. P., Pilosof, Shai, Bershtein, Shimon, Rotblat, Barak
Publicado 2020